Dr. Bhubaneswar Mandal

    Associate Professor
    Department of Chemistry
    IIT Guwahati, North Guwahati
    Assam - 781 039, Indiae

    email: bmandal@iitg.ernet.in
    Phone: +91 361 258 2319 (Office)
    +91 361 258 4319 (Residence)
    +91 995 717 1511 (Mobile)
    Fax: +91 361 258 2349

     

     

     

    Highlights from lab

     

    Our contributions:

     

    on Organic synthesis and Peptide chemistry:

    We have developed four environment friendly, cost-effective, and recyclable coupling reagents (renewable chemicals) which can be used for preparation of high quality peptides as well as for other transformations:

    1.    Boc-Oxyma: CAS No. 1426821-11-5 (Adv. Synth. Catal., 2013, 355, 448-462.)

    2. 2-NBsOXY: CAS No. 1441409-96-6 (J. Org. Chem. 2014, 79 (12), 5420–5431)

    3.  4-NBsOXY: CAS No. 1441409-91-1 (J. Org. Chem. 2014, 79 (9), 3765–3775.)

    4.  2,4-dNBsOXY: CAS No. 1441410-01-1 (Eur. J. Org. Chem., 2013, 2627–2633.)

     

    on Drug design:

    Introduced the concept of Pro-drug in the domain of drug design against protein misfolding diseases in the form of BBDP. In the concept of Beta Breaker Di-Peptides, BBDP,  an well designed peptide goes inside the cellular environment and gets converted to its active form in situ. These peptides align themselves easily with the disease forming fibrils, then disrupts fibrils as soon as the active form is achieved.

    (ACS Chemical Neuroscience, 2014, 5 (5), 400–408.)

    Concept of Beta Sheet Breaker Hybrid Peptides, (BSBHps), is also introduced and demonstrated that peptides designed following such concept may have excellent ability for inhibition of fibril formation as well as fibril disruption.

    (Chem. Commun., 2015, 51, 2245 - 2248. highlighted as cover page)

    Two Indian patent applications are filed on some of the physiologically relevant designed peptides. (Aplication  No. E-2/1727/2015/KOL & 201631018104)

     

    Felicitations:

    Congratulations to Srinu for the Best Poster Award in the International Conference on Sophisticated Instruments in Modern Research (ICSIMR-2017), 30th June to 1st july; Organiser: Central Instruments Facility, Indian Institute of Technology Guwahati.

     

    Congratulations to Dr. Dharm Dev for successfully defending his Ph. D. thesis entitled, "Development of ortho-NosylOXY as a Novel Coupling Reagent for Peptide Synthesis and Related Organic Transformations" on 25/11/2016.

     

    Congratulations to Dr. Ashim Paul for successfully defending his Ph. D. thesis entitled, "Development of New Strategies for Peptide Based Drug Design against Alzheimer’s Disease" on 06/06/2016.

     

    Congratulations to Ashim for receiving postdoctoral offer before defending his thesis.
     

    Congratulations to Ashim for his second patent application entitled, “β-SHEET BREAKER PEPTIDES FOR DRUG DESIGN AGAINST DIABETES TYPE-2” on 26.05.2016, application no. 201631018104.
     

    Congratulations to all my students (present and past). Our work on ortho-NosylOXY (the recyclable peptide coupling reagent) was recognized as the best one by the Industrial Green Chemistry Foundation for its potential on the cost reduction at source and waste
    minimization in chemical industries and got awarded IGCW-2015 (Industrial Green Chemistry World award - 2015) at Hotel Courtyard Marriott, Mumbai, on the 4th Dec, 2015. A trophy was handed over to myself (Dr. Bhubaneswar Mandal) by Dr. David Constable, Director, ACS Green Chemistry Institute and Dr. John Warner, who is regarded as the Father of Green Chemistry. Later I came to know that the entries were judged by them as well.

     

    Congratulations to Ashim, as he was awarded a certificate and a cash prize of
    Rs. 10,000/- as a winner of the THE TALENT SEARCH CONTEST ON INNOVATIVE
    RESEARCH IDEAS LEADING TO ENTREPRENEURIAL VENTURE IN BIOTECHNOLOGY AND
    ALLIED AREAS on 21st Nov - 2015, conducted by Guwahati Biotech Park.
    Title of the entry: "Peptide based drug development against Alzheimer’s
    disease".

     http://guwahatibiotechpark.com/news-and-events.php

     

    Congratulations to the team of Miss Sujan Kalita and Dr. Bhubaneswar Mandal for the Award of Rs. 10,000/- for being the finalist of the Samsung Innovation Award 2015 held on Oct 27, 2015 at IIT Guwahati. Title of the entry: "A suggested solution of auto cleaning system for washing machine’s drum, keeping the system’s efficiency intact”

     

    Congratulations to Dharm, Nani Babu, Kishore and Jyoti as their is again a special coverage published on their JOC paper in Organic Chemistry Portal.

    http://www.organic-chemistry.org/abstracts/lit4/529.shtm

     

    Congratulations to Kishore, Srinu and Dharm again as their is a special coverage published on their JOC paper in Organic Chemistry Portal.

    http://www.organic-chemistry.org/abstracts/lit4/473.shtm

     

    Congratulations to Mr. Ashim Paul for his  cover page in ChemCom and the patent application.

    Congratulations to Dharm Dev and Kishore as their works are picked by Prof. Douglass Taber of University of Delaware as one of the most significant current developments in organic synthesis in two consecutive issues of the Current Organic Chemistry Highlights column. Later these will be part of a book series.

    http://www.organic-chemistry.org/Highlights/2015/09March.shtm

    http://www.organic-chemistry.org/Highlights/2015/16March.shtm

     

    Congratulations to Dr. Thalluri Kishore for successfully defending his Ph. D. thesis entitled, "Development of Chemoselective and Stereoselective Strategies for Peptide Synthesis and Related Organic Transformations" on 17/10/2014.

    Congratulations to Mr. Thalluri Kishore for securing the post doctoral position at the famous group of Prof. Richard DiMarchi, Standiford H. Cox Distinguished Professor of Chemistry, Linda & Jack Gill Chair in Biomolecular Sciences, Indiana University, before defending his thesis.

    Congratulations to Dr. Krishna Chaitanya Nadimpally for being selected for CSIR-Nehru postdoctoral fellowship.

    Congratulations to Dr. Palakurthy Nani Babu for his postdoctoral position in the Centre for Nano and Soft Matter Sciences, Bangalore.

    Congratulations to Dr. Krishna Chaitanya Nadimpally for  Gandhian Young Technological Innovation Awards / Appreciations 2014. (link)

    Congratulations to Dr. Palakurthy Nani Babu for successfully defending his Ph. D. thesis entitled, "Direct synthesis of aryl sulfonate esters and their applications in organic transformations" on 31/01/2014.

    Congratulations to Dr. Krishna Chaitanya Nadimpally for successfully defending his Ph. D. thesis entitled, "Concept of β-Breaker Dipeptides and its Application in Alzheimer’s Amyloid Disruption" on 23/01/2014.