BT 201	Biochemical Process Calculations	2-1-0-6
Pre-requisites: NIL Syllabus Dimensions and Units: Dimensions and System of Units, Fundamental and derived units, Dimensional consistency, Dimensional equations, Different ways of expression of units of quantities and physical constant, Unit conversion and significance. Basic Biochemical Calculations: Mole, molecular weight, mole/mass fractions calculations, composition of gas, liquid and solid mixtures, Ideal gas law and other equations of state equations & applications, Dalton's law, Raoult's law, Henry's law, Solutions and properties. Material Balances without biochemical reaction: Process flow sheet, degree of freedom, Material balance with and without recycle; Bypass and purge streams, Material balances around equipments related to unit operations like filtration, extraction, distillation column, adsorption and drying/freeze drying. Material balance of unsteady state operations Material balance involving biochemical reaction: Concept of limiting and excess reactants, percentage conversion, yield and selectivity. Single and multiple reaction Lumped and Distributed processes, Material balance involving reactions with reference to penicillin, lactic acid, and ethanol and biopharmaceuticals production. Energy Balance: Law of thermodynamics, heat capacity of gas, liquid, solid and mixtures, sensible heat change in gas and liquid, enthalpy change in phase transformation, enthalpy change accompanied by biochemical reaction, Standard heat of reaction, heat of mixing and dissolution of solids, Hess's law, Humidity chart, Energy balance involving biochemical reaction. Case Studies: Flow chart based material and energy balance calculations. Text Books 1. David M. Himmelblau, James B. Riggs, PHI Learning Pvt. Ltd, 7th edition, 2006. Basic Principles & Calculations in Chemical Engineering", 2. Richard M. Felder, Ronald W. Rousseau, Wiley, 3rd edition, 2004. Elementary Principles of Chemical Processes. 3. Pauline M. Doran. Bioprocess Engineering Principles. 2nd ed. Elsevier Science & Technology Books. 1995. References 1. O.A.Hougen, K.M.Watson, R.A.Ragatz, CBS Publishers New Delhi, 2nd edition, 2004.Chemical Process Principles Part-I: Material and Energy Balances.