BT 208

Transport Phenomenon in Bioprocesses

3-1-0-8

 

Pre-requisites: Not required

 

Syllabus

 

Introduction and rheology: Definition of transport processes. Basic and derived units and nomenclature. Dimensionless numbers. General

aspects of rheology. Newton's Law. Non-Newtonian fluids and rheology of fermentation broths. Viscosity measurement. Case study.

Fluid flow in pipes: Predicting flow characteristics in pipe systems. Laminar flow and Hagen-Poiseuille equation. Calculating heads in a pipework system. Bernoulli equation. Case study: Bernoulli design problem. Pumping of Liquids (pumps classification, NPSH, cavitation, characteristic curve), Compressor. Flow and pressure measurement.

Fluid flow in packed-bed and Fluidized bed columns: Flow through porous media. Darcy's Law and Carman-Kozeny equation. Determining column porosity. Estimating pressure drops in packed beds. Effect of particle shape. Concept of wall support and effects of compressible media. Concept of critical velocity.

Heat transfer

Introduction: Mechanisms and applications of heat transfer-mode of heat transfer-conduction, convection and radiation.

Steady state heat transfer fundamentals: Resistances to heat transfer. Heat transfer in heat exchangers and fermenter coils, jacketed vessels. Principles of heat transfer underlying condensation and evaporation. Unsteady state heat transfer fundamentals.

Mass Transfer:

Diffusion and Mass transfer coefficient: Diffusivity and mechanism of mass transfer - derivation of the equations of mass transport by diffusion-stationary and unsteady mass transport by diffusion-convective mass transport-mass transfer coefficient, macroscopic balances for mass transport.

Application of Heat and Mass transfer: Absorption, Distillation principles, phase diagrams and equilibrium curves, non-ideal systems, continuous distillation, McCabe - Thiele method, column operation. Drying principles and operation.

 

Text Books

1.     Transport Phenomena, by Bird R.B., Steward W.E., and Lightfoot E.N., John Wiley & sons, Inc., New York, 2002

2.     C J Geankoplis, Transport Processes and Separation Processes Principles, 4th Edition, New Jersey, PHI Publishers, 2010

3.     Pauline M. Doran. Bioprocess Engineering Principles. 2nd ed. Elsevier Science & Technology Books. 1995

References

1.     Bailey, J. E., and D. F. Ollis. Biochemical Engineering Fundamentals. 2nd ed. New York, McGraw-Hill, 1986.

2.     H. W. Blanch and D. S. Clark, Biochemical Engineering, Marcel, Dekker Inc., 1996.