CH 221 |
Organic Chemistry |
3-1-0-8 |
Syllabus: Introduction
to types of organic reactions; Structure and stability of reactive
intermediates: carbocations, carbanions, free radicals, carbenes, arynes and nitrenes;
Methods of determining organic reaction mechanism: thermodynamic and kinetic
requirements, transition state theory, Hammond postulate, Curtin-Hammett
principle, kinetic vs. thermodynamic control reaction, isotope effects,
substituent effects, Hammett linear free energy relationship, Taft equation;
Addition reaction to C=C and C=O; Preliminary idea of radical reactions;
Application of Oxidation and Reduction reactions and reagents, Name reactions
(e.g. Sharpless epoxidation,
Suzuki coupling, Heck coupling etc.). Mechanism of aromatic nucleophilic and electrophilic substitions; Introduction to synthesis of nucleic acids
and peptide chemistry. Texts: 1. E. V. Anslyn and D. A.
Dougherty, Modern Physical Organic Chemistry, 1st Ed.,
University Science Books, California ,2006. 2. F. A. Carey and R. J. Sundberg,
Advanced Organic Chemistry: Structure and Mechanisms (Part A and
B), Kluwer Academic/ Plenum Pub., 2000 References: 1. P. Sykes, A guide to mechanism in Organic Chemistry, 6th Ed.,
Pearson Education, 2004. 2. M. B. Smith and J. March, Advanced
Organic Chemistry, 6th Ed.., John Wiley and Sons, Inc, 2007. 3. D. Nasipuri, Stereochemistry
of Organic Compounds, Wiley, 1994. |