Kapish Gupta
kapgupta[AT*]iitg.ac.in
Research Areas:
Toxicity Assay, Liver Mechanobiology, Cholestasis, Drug Testing, Biliary Atresia
Web page: https://sites.google.com/view/tmechlab
Current (2024-)
Development of in vitro drug testing assay
Post Doc (2019-2024)
Utilized mouse cholangiocyte spheroids and explants to identify novel environmental toxins, specifically microcystins, and elucidated the mechanisms of cellular damage implicated in biliary atresia, a rare pediatric fibrosing liver disease. Two first-author publications are currently in preparation.
Investigated the mechanical defects in bile duct resulting from Efemp-1 knockout—a gene associated with biliary atresia. A first-author publications in preparation.
Developing animal models of toxin induced biliary atresia.
Using patient derived cholangiocytes, I contributed to development of a vascularized bile-duct-on-chip model to investigate the involvement of immune cells in cholangiopathies.
PhD: (2014-2019)
Discovered novel role of pressure in regulating bile flow.
Worked on collaborated project to develop in vitro models for liver drug testing, malaria relapse, and developing methods to differentiate and obtain liver cells.
Master of Technology (2012-2014)
Developed cisplatin-coated magnetic nanoparticles which can deliver drug and can be used as MRI contrast agent for tracking drug delivery.
Bachelor of Technology (2008-2012)
Developed carrier-based and carrier-free methodologies for immobilization of Amylase and Amyloglucosidase
PhD in Mechanobiology from NUS Singapore from 2014 to 2019
Master of Technology in Biomedical Engineering from IIT Bombay with a GPA of 10/10, earning a silver medal for ranking first in the 2014 graduating class.
Bachelor of Technology in Biotechnology from NIT Jalandhar with a GPA of 9.39/10, earning the institute gold medal for ranking first in the 2012 graduating batch. In 2012, I secured an All-India Rank of 2 in the GATE (Biotechnology) exam and an All-India Rank of 5 in the CSIR UGC NET, receiving the SPM fellowship.
Research Assistant at the Mechanobiology Institute, National University of Singapore, from May 2019 to September 2019
Postdoctoral Fellow in the Division of Gastroenterology at the Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA, from September 2019 to July 2024.
Assistant Professor in the Department of Biosciences and Bioengineering at IIT Guwahati since July 2024
will be updated soon....
.Journals
1. Gupta K, Xu JP, Diamond T, de Jong IEM, Glass A, Llewellyn J, et al. "Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury.", PLoS One. DOI.10.1371/journal.pone.0301824 , Vol.19, 4, P.P - , (2024)
2. Gupta, K., Llewellyn, J., Roberts, E., Liu, C., Naji, A., Assoian, R. K., & Wells, R. G. "The biliary atresia susceptibility gene, EFEMP1, regulates extrahepatic bile duct elastic fiber formation and mechanics", JHEP Reports. DOI.10.1016/j.jhepr.2024.101215, Vol., , P.P - , (2024)
3. Gupta, K., Chen, D., Wells, R. G. "Microcystin-RR is a biliary toxin selective for neonatal extrahepatic cholangiocytes", JHEP Reports. DOI.10.1016/j.jhepr.2024.101218, Vol., , P.P - , (2024)
4. Gupta K "A Modular Analysis of Bile Canalicular Function and its Implications for Liver Cholestasis", American Journal of Physiology Gastrointestinal and Liver Physiology. DOI.10.1152/ajpgi.00165.2022 , Vol., , P.P - , (2023)
5. Du Y, DeJong IEM, Gupta K, Zinman OW, Zahav AH , Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck W, Wells RG. "Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease", Biofabrication. DOI.10.1088/1758-5090/ad0261, Vol.16, 1, P.P - , (2023)
Conference Publication
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