Department of Biotechnology, IIT Guwahati

         Department
              of
          Biosciences and Bioengineering
Indian Institute of Technology Guwahati

Contact Us:

Department of Biosciences & Bioengineering
Indian Institute of Technology Guwahati
Guwahati 781039

Telephone:
(0361) 258-2250
Fax: (0361) 258-2249
E-mail: biooff@iitg.ernet.in

Name: Dr. Siddhartha Sankar Ghosh

Designation: Professor

Department/Institute: Department of Biosciences and Bioengineering
                                      Indian Institute of Technology Guwahati (IITG)
                                      Guwahati 781039, Assam
                                      Email: sghosh@iitg.ac.in
                                      Home Page:  https://www.iitg.ac.in/Siddhartha Ghosh
                                      Google Scholar: https://scholar.google.com/Siddhartha Ghosh

Educational Qualifications

- Ph. D. (Mol. Biology): 1998, Indian Institute of Chemical Biology (IICB), Kolkata
- M. Sc. (Biochemistry): 1991, University College of Science, Kolkata
- B. Sc. (Chemistry Honors): 1988, Ramakrishna Vivekananda Mission College, Kolkata

Professional Experience

- Professor: July 2012 onwards, IITG
- Associate Professor: July 2007- June 2012, IITG
- Assistant Professor: March 2003-July 2007, IITG
- Post Doctoral Fellow: March 1998-February 2003, Albert Einstein College of Medicine, NY, USA

Administrative Experience

- Head, Centre for Nanotechnology: April 2009- June 2013, IITG

- Served as Member of Several Institute committee: Institute Biosafety Committee, Institute Animal Ethics Committee, DPPC Secretory

Teaching:

-Various undergraduate, post graduate and PhD level courses at the department, which include fundamental, advance and applied courses on molecular biology, gene therapy and related areas.

-Interdisciplinary open elective courses at the Centre for Nanotechnology for the students of other disciplines.

Current Research Areas

1. EMT Dynamics

2. Cancer Therapeutics

3. Nanotheranostics

4. Biomicrofluidics

1. EMT Dynamics:

Tweaking EMT and MDR dynamics to constrain triple-negative breast cancer invasiveness by EGFR and Wnt/β-catenin signaling regulation. Cellular Oncology. https://doi.org/10.1007/s13402-020-00576-8, 2020

Epithelial to mesenchymal transition (EMT) is known to contribute to cancer progression, invasiveness and multidrug resistance (MDR). There is a strong correlation between various drug efflux mechanisms, cancer stem cells and tumor microenvironments, which in turn is synchronized by complex signaling crosstalk between EMT and MDR. Targeting EGFR by either erlotinib (EGFR inhibitor) or lapatinib (EGFR/HER-2 inhibitor) alone was ineffective against metastatic triple-negative breast cancer (TNBC). Interestingly, we subsequently found that a low dose of lapatinib did act as a substrate rather than as an inhibitor facilitating EMT and MDR, leading to metastasis. Additional gene expression studies indicated that co-targeting the EGFR and Wnt/β-catenin pathways with lapatinib and a tankyrase inhibitor promoted mesenchymal to epithelial transition (MET). Application of these inhibitors led to increase in the epithelial marker E-cadherin and decrease in the stemness marker EpCAM, with concomitant reductions in the ABC transporters ABCB1 and ABCG2, respectively. These co-targeting effects resulted in overcoming EMT and MDR, which in turn was highlighted by reduced levels of pEGFR, pAKT, pMAPK, pSTAT-3, pGSK-3β and β-catenin. This work indicates the synergistic action of targeting EGFR and Wnt/β-catenin signaling pathways in combatting cancer

Schematic illustration of (a) overall observable cellular events and (b) details of intracellular signaling upon lapatinib-XAV939 co-treatment regulating EMT and MDR dynamics

2. Cancer Therapeutics:

A. Protein Therapy: Transmembrane TNFa Dynamics in Cancer Therapeutics.

Cytokine, DOI: 10.1016/j.cyto.2020.155303, 2020

Molecular Biology Reports, 47, 3949–3961, 2020

Cytokines are a group of glycoprotein signaling mediators, which play essential roles in maintaining several complex physiological functions of our body. TNFα is such a pleiotropic cytokine, which involves maintaining a plethora of immune responses. Initially, TNFα is synthesized as a 26 kDa full-length transmembrane form, which is enzymatically cleaved to produce the soluble circulating 17 kDa TNFα. Although the anti-cancer potential of soluble TNFα was discovered more than a century back, its dual ability to promote tumor, posed a major hindrance in finding its acceptance as a proper anti-cancer molecule. In contrast, the membrane-tethered tmTNFα holds the potential of tumor regression without initiating cell proliferation. The membrane-tethered form of TNFα is the physiological precursor of soluble TNFα that remains biologically active and is capable of initiating signaling cascades after binding with the TNFα receptors- TNFR I and TNFR II. We emphasize on the basic biology and molecular aspects of tmTNFα for its anti-cancer potential

B. Cancer Gene Therapy: Our group focuses on development of new generation gene therapy vectors. This mainly includes development of suicide gene therapy for cancer. The efficacy and the molecular mechanism associated with suicide gene therapy are the primary objectives of our investigations. Rational Designing of suicide proteins with improved specificity towards the prodrug for gene therapy application is another major thrust. We have also been able to demonstrate apoptotic signaling pathways involving suicide gene therapy. The detail molecular investigation would help us to choice the right vector for cancer gene therapy.

Schematic of Suicide Gene Therapy

3. Nanotheranostics:

Transferrin-conjugated Red Blood Cell membrane-coated Poly (lactic-co-glycolic acid) nanoparticles.

ACS Applied Nano Materials. 3, 4, 3807-3819, 2020

Epithelial to mesenchymal transition (EMT) induces cell migration, invasion, and drug resistance, and consequently, contributes to cancer metastasis and disease aggressiveness. This study attempted to address crucial biological parameters to correlate EMT and drug-treated cancer cells traversing through microcapillaries, reminiscent of metastatic conditions. MDA-MB-468 breast cancer cells induced to undergo EMT were initially passed through several blockages and then through a constricted microchannel, mimicking the flow of invasive metastatic cells through constricted blood microcapillaries. EMT cells acquired enhanced migratory properties and retained 50% viability, even after migration through wells and a constricted passage of 7 μm and 150 μm in length at a constant flow rate. The hydrodynamic properties revealed cellular deformation with a deformation index, average transit velocity, and entry time. Interestingly, cells collected at the channel outlet regained epithelial character, undergoing reverse transition (mesenchymal to epithelial transition, MET) in the absence of EGF. Remarkably, real-time polymerase chain reaction (PCR) analysis confirmed increases in the vimentin and fibronectin expression in EMT cells, respectively; however, their expression reduced to basal level in the MET cells. The work highlights the hydrodynamic and drug-evading properties of cells that have undergone an EMT, when passed through a constricted microcapillary that mimics their journey in blood circulation.

Schematic representation of the motion of metastatic cancer cells from the primary site to a distant secondary site through microcapillaries.

Sponsored Research Projects:

Ongoing projects:

Project Coordinator, DBT Program support on “Fundamental Molecular Investigations in Biotechnology Phase -II” (2016- 2021). Implemented at the Department of Biosciences and Biotechnology, IITG.
Principle Investigator, DBT supported project entitled "Modulation of Connexin-43 and Histone Deacetylase to Comprehend Cancer Therapy” (2018- 2021). Implemented at the Centre for Nanotechnology, IITG. Twinning project with IIT Roorkee.
Principle Investigator, DBT supported project entitled “Novel nanocluster based targeted anticancer theranostics” (2016- 2021). Implemented at the Centre for Nanotechnology, IITG
Co-Principle Investigator, DEITY supported project entitled “Centre for Excellence in Research and Development of Nanoelectronic Theranostic Devices” (2014-2021). Implemented at the Centre for Nanotechnology, IITG

Completed Projects:

Project Coordinator, DBT Program support on “Fundamental Molecular Investigations in Biotechnology Phase -I” (2008- 2014).
Principle Investigator, DBT supported project entitled “Novel Nanoscale Materials Targeted towards Antimicrobial and Anticancer Activities” (2010- 2014).
Principle Investigator, MHRD funded project entitled “Construction of Prodrug Gene Expression Systems” (2004-2006). Implemented at the Department of Biotechnology
Principle Investigator, CSIR funded project entitled “Sleeping Beauty (SB) Transposon Mediated Sequence Specific Delivery and Activation of Prodrug Gene in Hepatocellular Carcinoma Cells” (2006-2009). Implemented at the Department of Biotechnology
Principle Investigator, DBT funded project entitled “Nanoscale Materials with Therapeutic Implications” (2007-2011). Implemented at the Centre for Nanotechnology
Co- Investigator, DBT funded project entitled, “ Inhibitor Based Selection of Blocking Antibodies against Heparin-binding EGF-like Growth Factor: Developing Potent Molecules for Antibody-based Cancer Therapy” (2007-2010), Implemented at the Department of Biotechnology
Co- Investigator, DRDO funded project entitled, “Development of Nanoscale Materials for Bacteria Removal from Surface Water” (2010-2012). Implemented at the Centre for Nanotechnology.
Associate Faculty Investigator, DST funded project entitled “Engineering nanoscale materials and their applications in nanotechnology” (2005-2010). Implemented at the Centre for Nanotechnology.
Associate Faculty Investigator, DST funded project entitled “Novel Nanoscale Materials: Generation, Characterization, and Device Applications” (2005-2010). Implemented at the Centre for Nanotechnology.

Journal Publications:

1. Tweaking EMT and MDR dynamics to constrain triple-negative breast cancer invasiveness by EGFR and Wnt/β-catenin signaling regulation. Shome R, Ghosh SS. Cellular Oncology, DOI: 10.1007/s13402-020-00576-8, 2020.

2. Unfolding transmembrane TNFα dynamics in cancer therapeutics. Bhattacharyya S, Ghosh SS. Cytokine, DOI: 10.1016/j.cyto.2020.155303, 2020.

3. Magnetotactic T-Budbots to Kill-n-Clean Biofilms. Bhuyan T, Simon AT, Maity S, Singh AK, Ghosh SS, Bandyopadhyay D. ACS Appl. Mater. Interfaces, 12, 39, 43352–43364, 2020.

4. Deciphering insights of novel recombinant tmTNFα in cell growth inhibition. Bhattacharyya S. Ghosh SS. Molecular Biology Reports, 47, 3949–3961, 2020.

5. Protein Therapeutics from Monolayer to Spheroids-A Model for Preclinical Investigations. Arora N, Ghosh SS. Journal of Cancer Immunology, 2 (2), 2020.

6. Nanoparticle Mediated Alteration of EMT Dynamics: An Approach to Modulate Cancer Therapeutics. Sen P, Saha M and Ghosh SS. Materials Advances, 1 (8), 2614-2630, 2020.

7. Transferrin-Conjugated Red Blood Cell Membrane-Coated Poly (lactic-co-glycolic acid) Nanoparticles for the Delivery of Doxorubicin and Methylene Blue. Bidkar AP, Sanpui P, Ghosh SS. ACS Applied Nano Materials, 3, 4, 3807-3819, 2020.

8. Nerve growth factor from Indian Russell’s viper venom (RVV-NGFa) shows high affinity binding to TrkA receptor expressed in breast cancer cells: Application of fluorescence labeled RVV-NGFa in the clinical diagnosis of breast cancer. Islam T, Majumder M, Bidkar AP, Ghosh SS, Mukhopadhyay R, Utkin Y, Mukherjee AK. Biochimie, 176, 31-44, 2, 2020.

9. A conformational tweak for enhanced cellular internalization, photobleaching resistance and prolonged imaging efficacy. Meher N, Bidkar AP, Barman D, Ghosh SS and Iyer PK. Chemical Communications, 56, 14861-14864, 2020.

10. Newly synthesized 3-sulfenylindole derivatives from 4-hydroxydithiocoumarin using an oxidative cross dehydrogenative coupling reaction (OCDCR): potential lead molecules for. Mondal S, Mahato K, Arora N, Kankane D, Singh UP, Ali S, Khan AH, Ghosh SS, Khan AT. Organic & Biomolecular Chemistry, 18 (21), 4104-4113, 2020.

11. Magnetotactic curcumin iButtonbots as efficient bactericidal agents. Bhuyan T, Singh Ak, Ghosh SS, Bandyopadhyay D. Bulletin of Materials Science, 43:111, 2020.

12. Transmembrane TNFα-Expressed Macrophage Membrane-Coated Chitosan Nanoparticles as Cancer Therapeutics. Bhattacharyya S, Ghosh SS. ACS Omega. 5(3): 1572–1580, 2020.

13. Integration of Nonsteroidal Anti-Inflammatory Drug with Luminescent Copper for in vivo Cancer Therapy in Mouse Model. Das M, Goswami U, Bhattacharyya S, Kandimalla R, Chattopadhyay A, Ghosh SS. ACS Applied Bio Materials, 3, 1, 227-238, 2020.

14. A facile synthesis of nontoxic luminescent carbon dots for detection of chromium and iron in real water sample and bio-imaging. Sinha R, Bidkar AP, Rajasekhar R, Ghosh SS, Mandal TK. The Canadian Journal of Chemical Engineering, 98 (1), 194-204, 2020.

15. Iron-Copper Bimetallic Nanocomposite Reinforced Dressing Materials for Infection Control and Healing of Diabetic Wound. Das M, Goswami U, Kanimbla R, Kalita S, Ghosh SS, Chattopadhyay A. ACS Applied Bio Materials, 2, 12, 5434-5445, 2019.

16. Copper Nanocluster-Doped Luminescent Hydroxyapatite Nanoparticles for Antibacterial and Antibiofilm Applications. Simon AT, Dutta D, Chattopadhyay A, Ghosh SS. ACS Omega, 4, 3, 4697-4706, 2019.

17. Gold-Nanocluster-Embedded Mucin Nanoparticles for Photodynamic Therapy and Bioimaging. Sailapu SK, Dutta D, Simon AT, Ghosh SS, Chattopadhyay A. Langmuir, 35, 32, 10475-10483, 2019.

18. Acoustic Propulsion of Vitamin C loaded Teabots for Targeted Oxidative Stress and Amyloid Therapeutics. Bhuyan T, Dutta D, Bhattacharjee M, Singh AK, Ghosh SS, Bandyopadhyay D. ACS Applied Bio Materials, 2, 10, 4571-4582, 2019.

19. Smartphone controlled interactive portable device for theranostics in vitro. Sailapu SK, Dutta D, Simon AT, Ghosh SS, Chattopadhyay A. Biosensors & Bioelectronics, 146:111745, 2019.

20. Deciphering therapeutic potential of PEGylated recombinant PTEN-silver nanoclusters ensemble on 3D spheroids. Arora N, Shome R, Ghosh SS. Molecular Biology Reports, 8, 1-10, 2019.

21. Deciphering Hydrodynamic and Drug-Resistant Behaviors of Metastatic EMT Breast Cancer Cells Moving in a Constricted Microcapillary. Nath B, Bidkar AP, Kumar V, Dalal A, Kumar Jolly MK, Ghosh SS, Biswas G. Journal of Clinical Medicine, 8, 1–10, 2019.

22. Rapid and label-free bacteria detection using a hybrid tri-layer dielectric integrated n-type organic field effect transistor Dey A, Singh A, Dutta D, Ghosh SS, PK Iyer. Journal of Materials Chemistry A, 7, 18330 –18337, 2019.

23. Red Blood Cell (RBC) Membrane Coated Poly (lactic-co-glycolic acid) Nanoparticles for Enhanced Chemo and Hypoxia Activated Therapy Bidkar AP, Sanpui P, Ghosh SS. ACS Applied Bio Materials, 2 (9), 4077 – 4086, 2019.

24. Combination Therapy with MAPK-Pathway Specific Inhibitor and Folic Acid Receptor Targeted Selenium Nanoparticles Induces Synergistic Anti-proliferative Response in BRAF-mutant Cancer Cells Bidkar AP, Sanpui P, Ghosh SS. ACS Biomaterials Science & Engineering, 5, 5, 2222-2234 [ACS Publishing Group], 2019.

25. Connexin-43 Enhances the Redesigned Cytosine Deaminase Activity for Suicide Gene Therapy in Human Breast Cancer Cells. Raza A, Ghosh SS. Biochemistry Insights, 12: 1–8, DOI: 10.1177/1178626418818 [SAGE Publishing Group], 2019.

26. Access to Multifunctional AEEgens via Ru (II)-Catalyzed Quinoxaline-Directed Oxidative Annulation.Ghosh S, Pal S, Rajamanickam S, Shome R, Mohanta PR, Ghosh SS, Patel BK. ACS Omega, 4, 3, 5565-5577 [ACS Publishing Group], 2019.

27. Understanding flow dynamics, viability and metastatic potency of cervical cancer (HeLa) cells through constricted microchannel. Nath B, Raza A, Sethi V, Dalal A, Ghosh SS and Biswas G. Scientific Reports, 8(1): 17357, DOI: 10.1038/s41598-018-35646-3 [Nature Publishing Group], 2018.

28. Bimetallic Fe-Cu-Nanocomposites on Sand-Particles for Inactivation of Clinical Isolates and Point of Use Water Filtration. Das M, Goswami U, Ghosh SS, Chattopadhyay A. ACS Applied Bio Materials, 1, 6, 2153-2166 [ACS Publishing Group], 2018.

29. Polyethylene Glycol-Encapsulated Histone Deacetylase Inhibitor Drug-Composite Nanoparticles for Combination Therapy with Artesunate. Goswami U, Raghuram K, Kalita S, Chattopadhyay A Ghosh SS. ACS Omega, 3 (9), 11504–1151 [ACS Publishing Group], 2018.

30. In Situ Synthesis of Luminescent Au Nanoclusters on a Bacterial Template for Rapid Detection, Quantification, and Distinction of Kanamycin-Resistant Bacteri. Goswami U, Sahoo A, Chattopadhyay A Ghosh SS. ACS Omega, 3 (6), 6113–6119 [ACS Publishing Group], 2018.

31. Multi-facet implications of PEGylated lysozyme stabilized-silver nanoclusters loaded recombinant PTEN cargo in cancer theranostics. Arora N, Gavya SL, Ghosh SS. Biotechnology and Bioengineering, 115(5), 1116-1127 [WILEY Publishing Group], 2018.

32. dGTP Templated Luminescent Gold Nanocluster Based Composite Nanoparticles for Cancer Theranostics Chatterjee B, Ghoshal A, Chattopadhyay A, Ghosh SS. ACS Biomaterials Science & Engineering, 4 (3), 1005–1012. [ACS Publishing Group], 2018.

33. An oxidative cross-coupling reaction of 4-hydroxydithiocoumarin and amines/thiols using a combination of I2 and TBHP: access to lead molecules for biomedical applications Mahato K, Arora N, Bagdi PR, Gattu R, Ghosh SS, Khan AT. Chemical Communications, 54, 1513-1516 [Royal Society of Chemistry], 2018.

34. Single Platform for Gene and Protein Expression Analyses Using Luminescent Gold Nanoclusters Sailapu SK, Dutta D, Sahoo AK, Ghosh SS, Chattopadhyay A. ACS Omega, 3 (2), 2119–2129 [ACS Publishing Group], 2018.

35. DNA-Templated Single Thermal Cycle Based Synthesis of Highly Luminescent Au Nanoclusters for Probing Gene Expression Sahoo AK, Sailapu SK, Dutta D, Banerjee S, Ghosh SS, Chattopadhyay A ACS Sustainable Chemistry & Engineering, 6 (2), 2142–2151 [ACS Publishing Group], 2018.

36. Fluorescence resonance energy transfer-based wash-free bacterial imaging and antibacterial application using a cationic conjugated polyelectrolyte. Zehra N, Dutta D, Malik AH, Ghosh SS and Iyer PK. ACS Applied Materials and Interfaces, 10, 27603-27611 [ACS Publishing Group], 2018.

37. Anticoagulant mechanism, pharmacological activity, and assessment of preclinical safety of a novel fibrin (ogen) olytic serine protease from leaves of Leucas indica. Gogoi D, Arora N, Kalita B, Sarma R, Islam T, Ghosh SS, Devi R, Mukherjee A K. Scientific Reports, 18; 8(1):6210. [Nature Publishing Group], 2018.

38. Phenylboronic acid templated gold nanoclusters for mucin detection using a smartphone based device and targeted cancer cell theranostics. Dutta D, Sailapu SK, Chattopadhyay A, Ghosh SS. ACS Applied Materials & Interfaces, 10 (4), 3210–3218 [ACS Publishing Group], 2018.

39. Transferrin−Copper Nanocluster−Doxorubicin Nanoparticles as Targeted Theranostic Cancer Nanodrug. Goswami U, Dutta A, Raza A, Raghuram K, Kalita S, Ghosh SS, Chattopadhyay A. ACS Applied Materials & Interfaces, 10 (4), 3282–3294 [ACS Publishing Group], 2018.

40. Developing single entity theranostic: Drug based luminescent nanoclusters with augmented cytotoxicity. Chatterjee B, Raza A, Ghosh SS. Nanomedicine, 13(3), 283-295 [Future Science Group], 2018.

41. White light emission from gold nanoclusters embedded bacteria. Goswami U, Basu, S, Raza A, Paul A, Ghosh SS, Chattopadhyay A. Journal of Materials Chemistry C, 5, 12360--12364 [Royal Society of Chemistry], 2017.

42. Efficient induction of apoptosis in cancer cells by paclitaxel-loaded selenium nanoparticles. Bidkar AP, Sanpui P, Ghosh SS. Nanomedicine, 13(3), 283-295 [Future Science Group], 2017.

43. Retention of Functional characteristics of Gulathione-S-Transferase and Lactate Dehydrogenase-A in Fusion Protein Lalitha GS, Arora N, Ghosh SS. Preparative Biochemistry & Biotechnology, DOI: 10.1080/10826068.2017.1405022 [Taylor & Francis Publishing Group], 2017.

44. Connexin-43 enhances tumor suppressing activity of artesunate via gap junction-dependent as well as independent pathways in human breast cancer cells. Raza A, Ghoshal A, Chockalingam S, Ghosh SS. Scientific Reports, 7, 7580, DOI:10.1038/s41598-017-08058-y [Nature publishing Group], 2017.

45. Phytaspase-loaded, Mn-doped ZnS quantum dots when embedded into chitosan nanoparticles leads to improved chemotherapy of HeLa cells using in cisplatin. Narayanan S, D Dutta, N Arora, Sahoo L, Ghosh SS. Biotechnology Letters, 39 (10), 1591–1598 [Springer Publishing Group], 2017.

46. Studying in vitro phagocytosis of apoptotic cancer cells by recombinant GMCSF-treated RAW 264.7 macrophages. Vanitha S, Bidkar AP, Shome R, Banerjee A, Chaubey N, Ghosh SS, Sanpui P. International Journal of Biological Macromolecules, 102, 1138-1145 [Elsevier Publishing Group], 2017.

47. Detection of Glutathione by Glutathione-S-Transferase- Nanoconjugate Ensemble Electrochemical Device. Barman U, Mukhopadhyay G, Goswami N, Ghosh SS, Paily P. Roy. IEEE Transactions on NanoBioscience, 16 (4), 271-279 [IEEE Publishing Group], 2017.

48. Magnetic Field Guided Chemotaxis of iMushbots for Targeted Anticancer Therapeutics. Bhuyan T, Singh AK, Dutta D, Unal A, Ghosh SS, Bandyopadhyay D. ACS Biomaterials Science & Engineering, 3(8), 1627–1640 [ACS Publishing Group], 2017.

49. Heterologous expression and functional characterization of phytaspase, a caspase-like plant protease. Narayanan S, Sanpui P, Sahoo L, Ghosh SS. International Journal of Biological Macromolecules, 95, 288-293 [Elsevier publishing group], 2017.

50. Tobacco phytaspase: Successful expression in a heterologous system. Narayanan S, Sanpui P, Sahoo L, Ghosh SS, Bioengineered, DOI:10.1080/21655979.2017.1292187 [Taylor & Francis Publishing Group], 2017.

51. Cationic BSA Templated Au-Ag Bimetallic Nanoclusters as a Theranostic Gene Delivery Vector for HeLa Cancer Cells. Dutta D, Chattopadhyay A, Ghosh SS. ACS Biomaterials Science & Engineering, 2(11), 2090-2098 [ACS publishing group], 2016.

52. Interactive luminescent gold nanocluster embedded dsDNA and cisplatin as model nanoparticles for cancer theranostics. Chatterjee B, Sahoo AK, Chattopadhyay A, Ghosh SS. RSC Advances, 6, 113053-113057 [RSC publishing group], 2016.

53. Functional Characterizations of Interactive Recombinant PTEN-Silica Nanoparticles for Potential Biomedical Applications. Arora N, Ghosh SS. RSC Advances, 6, 114944-114954 [RSC publishing group], 2016.

54. Recombinant sFRP4 bound Chitosan-Alginate Composite Nanoparticles Embedded with Silver Nanoclusters for Wnt/beta-catenin targeting in Cancer Theranostics. Ghoshal A, Goswami U, Raza A, Chattopadhyay A, Ghosh SS. RSC Advances, 6, 85763-85772 [RSC publishing group], 2016.

55. Silver nanoclusters embedded composite nanoparticles for targeted prodrug delivery in cancer theranostic. Sahoo A, Goswami U, Dutta D, Banerjee S, Chattopadhyay A, Ghosh SS. ACS Biomaterials Science & Engineering, 2 (8), 1395-1402 [ACS publishing group], 2016

56. Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (hGM-CSF): Possibility of Nanoparticle-Mediated Delivery in Cancer Immunotherapy. Vanitha S., Goswami U, Chaubey N, Ghosh SS and Sanpui P. Bioengineered, DOI: 10.1080/ 21655979.2016.1212136 [Taylor & Francis Publishing Group], 2016.

57. Antagonizing Canonical Wnt Signaling Pathway by Recombinant Human sFRP4 Purified from E. coli and its Implications in Cancer Therapy. Ghoshal A and Ghosh SS. Molecular and Cellular Biochemistry, 418 (1-2), 119-135. [Springer publishing group], 2016.

58. Unravelling the potential of a new uracil phosphoribosyltransferase (UPRT) from Arabidopsis thaliana in sensitizing HeLa cells towards 5-fluorouracil. Narayanan S, Sanpui P, Sahoo L, Ghosh SS. International Journal of Biological Macromolecules, 91,310-316 [Elsevier publishing group], 2016.

59. Bimetallic silver nanoparticle-gold nanocluster embedded composite nanoparticles for cancer theranostics. Dutta D, Sahoo AK, Chattopadhyay A, Ghosh SS. Journal of Materials Chemistry B, 4, 793-800 [RSC publishing group], 2016.

60. Functional Characterization of Recombinant Human Granulocyte Colony Stimulating Factor (hGMCSF) Immobilized onto Silica Nanoparticles. Vanitha S, Goswami U, Chaubey N, Ghosh SS and Sanpui P. Biotechnology Letters, 38 (2), 243-249 [Springer publishing group], 2016.

61. Targeting Wnt Canonical Signaling by Recombinant sFRP1 Bound Luminescent Au-Nanocluster Embedded Nanoparticles in Cancer Theranostics. Ghoshal A, Goswami U, Sahoo AK, Chattopadhyay A, Ghosh SS. ACS Biomaterials Science & Engineering, 1 (12), 1256–1266 [ACS publishing group], 2015.

62. Phytogenic “green synthesis” of silver nanoparticles with enhanced antibacterial and anticancer activity. Marvi DK, Sahoo AK, Goswami U, Prasad DS, Sahoo L, Ghosh SS. International J Pharm Bio Sci., 6 (4), 482 – 493 [IJPBS publishing group], 2015.

63. Redesigned E.coli cytosine deaminase: a new facet of suicide gene therapy. Md Asif Raza, V. Kohila, Ghosh SS. The Journal of Gene Medicine, 7(6-7), 132-9 [Wiley publishing group], 2015.

64. Cu(2+)- embedded Carbon Nanoparticle as an Anticancer Agent. Md Palashuddin Sk, Goswami U, Ghosh SS and Chattopadhyay A. Journal of Materials Chemistry B, 3, 5673-5677 [RSC publishing group], 2015.

65. Gold Nanocluster Embedded Albumin Nanoparticles for Two-Photon Imaging of Cancer Cells Accompanying Drug Delivery. Khandelia R, Bhandari S, Pan UN, Ghosh SS and Chattopadhyay A, Small, 11(33), 4075-4081 [Wiley publishing group], 2015.

66. Expression, Purification, and Therapeutic Implications of Recombinant sFRP1. Ghoshal A and Ghosh SS. Applied Biochemistry and Biotechnology, 175 (4), 2087-2103. [Springer publishing group], 2015.

67. Overexpression of Granulocyte Macrophage Colony Stimulating Factor in Breast Cancer Cells Leads Towards Drug Sensitization. Chaubey N and Ghosh SS. Applied Biochemistry and Biotechnology, 175 (4), 1948-1959 [Springer publishing group], 2015.

68. Synergistic Anticancer Activity of Fluorescent Copper Nanoclusters and Cisplatin Delivered through a Hydrogel Nanocarrier. Ghosh R, Goswami U, Ghosh SS, Paul A and Chattopadhyay. ACS Applied Materials and Interfaces, 7(1), 209-222 [ACS publishing group], 2015.

69. Synthesis, characterization and enhanced bactericidal action of a chitosan supported core–shell copper–silver nanoparticle composite. Mallick S, Sanpui P, Ghosh SS, Chattopadhyay A, Paul A. RSC Advances, 5, 12268-12276 [RSC publishing group], 2015.

70. Elucidation of procoagulant mechanism and pathophysiological significance of a new prothrombin activating metalloprotease purified from Daboia russelii russelii venom. Thakur R, Chattopadhyay D, Ghosh SS and Mukherjee AK. Toxicon, 100, 1-12, 2015.

71. Chemosensitization of IκBα overexpressing glioblastoma towards anti-cancer agents. Banerjee S, Sahoo AK, Chattopadhyay A, Ghosh SS. RSC Advances, 4, 39257-39267 [RSC publishing group], 2014.

72. Macrophage Colony Stimulating Factor and Cancer. Chockalingam S and Ghosh SS Tumor Biology, 35(11), 10635-10644 [Springer publishing group], 2014.

73. Recombinant IκBα-loaded curcumin nanoparticles for improved cancer therapeutics. Banerjee S, Sahoo AK, Chattopadhyay A, Ghosh SS. Nanotechnology, 25 (2014) 345102 (11pp), [IOP publishing group], 2014.

74. Hierarchical Logic Structures Based on Responsive Fluorescent Gold Nanoclusters. .Sailapu SK, Sahoo AK, Ghosh SS and Chattopadhyay A. Small, 29, 10(20), 4067-71 [Wiley publishing group], 2014.

75. Polymer coated Gold Nanoparticle-Protein Agglomerates as Nanocarriers for Hydrophobic Drug Delivery. Khandelia R, Jaiswal A, Ghosh SS and Chattopadhyay A. Journal of Materials Chemistry B, 2 (38), 6472 – 6477 [RSC publishing group], 2014.

76. Silver nanoparticle loaded PLGA composite nanoparticles for improving therapeutic efficacy of recombinant IFNγ by targeting the cell surface. Chaubey N, Sahoo A, Chattopadhyay A and Ghosh SS. Biomaterials Science, 2, 1080-1089 [RSC publishing group], 2014.

77. Blue Emitting Copper Nanoclusters Synthesized in the Presence of Lysozyme as Candidates for Cell Labeling. Ghosh R, Sahoo A, Ghosh SS, Paul A and Chattopadhyay A ACS Applied Materials & Interfaces, 6(6), 3822-3828. [ACS publishing group], 2014.

78. Silver Nanoparticles impregnated Alginate-Chitosanblended Nanocarrier Induces Apoptosis in Human Glioblastoma Cells. Sharma S, Chockalingam S, Sanpui P, Chattopadhyay A and Ghosh SS. Advanced Healthcare Materials, 3, 106–114. [Wiley publishing group], 2014.

79. Characterization, mechanism of anticoagulant action, and assessment of therapeutic potential of a fibrinolytic serine protease (Brevithrombolase) purified from Brevibacillus brevis strain FF02B. Majumdar S, Sarmah B, Gogoi D, Banerjee S, Ghosh SS, Chattopadhyay P, AK Mukherjee AK. Biochimie, 103, 50-60 [Elsevier publishing group], 2014.

80. Molecular Characterization and Expression of a Novel Alcohol Oxidase from Aspergillus terreus MTCC6324. Chakraborty M, Ghosh SS and Goswami P. PLoS ONE, 9(4): e95368. [Public Library of science publishing group], 2014.

81. Folic acid conjugated-bio Polymeric nanocarriers: synthesis, characterization and In vitro delivery of prodrug converting enzyme. Yata V, Banerjee S, Ghosh SS. Advanced Science, Engineering and Medicine, 6 (4), 388-392 [American Scientific Publishing group], 2014.

82. Recovering Hidden Quanta of Cu2+-doped ZnS Quantum Dots in Reductive Environment. Begum R, Sahoo A, Ghosh SS and Chattopadhyay A. Nanoscale, 6, 953-96, [RSC publishing group], 2014.

83. Simultaneous RGB emitting Au nanoclusters in chitosan nanoparticles for anticancer gene theranostic. Sahoo A, Banerjee S, Ghosh SS and Chattopadhyay A. ACS Applied Materials & Interfaces, 6 (1), 712–724. [ACS publishing group], 2014.

84. Carbon dots mediated room-temperature synthesis of gold nanoparticles in poly (ethylene glycol). Jaiswal A, Gautam PK, Ghosh SS and Chattopadhyay A. Journal of Nanoparticle Research, 16 (1), 1-14. [Springer publishing group], 2014.

85. Amelioration of cancer stem cells in Macrophage Colony Stimulating Factor-Expressing U87MG-human glioblastoma upon 5-fluorouracil therapy. Chockalingam S and Ghosh SS. PLoS ONE, 8 (12), e83877. [Public Library of science publishing group], 2013.

86. Hydrogel nanocarrier encapsulated recombinant IκBα as a novel anticancer protein therapeutics. Banerjee S, Sahoo A, Chattopadhyay A and Ghosh SS. RSC Advances, 3 (33), 14123 - 14131 [RSC publishing group], 2013.

87. Gold nanoparticle–protein agglomerates as versatile nanocarriers for drug delivery. Khandelia R, Jaiswal A, Ghosh SS, and Chattopadhyay A. Small,9(20),3494-505 [Wiley publishing group], 2013.

88. Molecular Cloning, Purification and Functional 4Implications of Recombinant GST Tagged hGMCSF Cytokine. Chaubey N and Ghosh SS. Applied Biochemistry Biotechnology, 169(5),1713-1726 [Springer publishing group], 2013.

89. Rationally designed Escherichia coli cytosine deaminase mutants with improved specificity towards the prodrug 5-fluorocytosine for potential gene therapy applications. V. Kohila, Jaiswal A, Ghosh SS. Med. Chemical Communications, 3, 1316-1322 [RSC publishing group], 2012.

90. A quantum dot impregnated-chitosan film for heavy metal ion sensing and removal. Jaiswal A, Ghosh SS and Chattopadhyay A. Langmuir, 28 (44), 15687–15696 [ACS publishing group], 2012.

91. Differential mode of attack on membrane phospholipids by an acidic phospholipase A2 (RVVA-PLA2-I) from Daboia russelli venom. Saikia D, Bordoloi NK, Chattopadhyay P, Chockalingam S, Ghosh SS, Mukherjee AK. Biochim Biophys Acta. 18(12), 3149-3157. [Elsevier publishing group], 2012.

92. Fabrication of Antibacterial Silver Nanoparticle – Sodium Alginate – Chitosan Composite Films. Sharma S, Sanpui P, Chattopadhyay A and Ghosh SS. RSC Advances, 2, 5837–5843 [RSC publishing group], 2012.

93. Presence of Amorphous Carbon Nanoparticles in Food Caramels. Md Palashuddin Sk, Jaiswal A, Paul A, Ghosh SS, Chattopadhyay A, Paul A. Scientific Reports, DOI:10.1038/srep00383 [Nature publishing group], 2012.

94. Emerging Implications of Nonmammalian Cytosine Deaminases on Cancer Therapeutics. Yata VK, Gopinath P and Ghosh SS. Applied Biochemistry Biotechnology, 167(7), 2103-2116 [Springer publishing group], 2012.

95. Iodine - Stabilized Cu Nanoparticle Chitosan Composite for Antibacterial applications. Mallick S, Sharma S, Banerjee M, Ghosh SS, Chattopadhyay A, Paul A. ACS Applied Materials & Interfaces, 4(3),1313-1323 [ACS publishing group], 2012.

96. Investigating structure and fluorescence properties of green fluorescent protein released from chitosan nanoparticles. Yata VK and Ghosh SS. Materials Letters, 73, 209–211[Elsevier publishing group], 2012.

97. Quick and simple estimation of bacteria using a fluorescent paracetamol dimer-Au nanoparticle composite. Sahoo A.K, Sharma S, Chattopadhyay A and Ghosh SS. Nanoscale, 4 (5), 1688 – 1694 [RSC publishing group], 2012.

98. One step synthesis of C-dots by microwave mediated caramelization of poly(ethylene glycol). Jaiswal A, Ghosh SS and Chattopadhyay A. Chemical Communications, 48(3), 407-409 [RSC publishing group], 2012.

99. Functional chitosan nanocarriers for potential applications in gene therapy. Jaiswal A, Chattopadhyay A and Ghosh SS. Materials Letters, 68(1), 261-264 [Elsevier publishing group], 2012.

100. Enhanced antibacterial activity of bimetallic gold-silver core-shell nanoparticles at low silver concentration. Banerjee M, Sharma S, Chattopadhyay A and Ghosh SS. Nanoscale, 3(12), 5120-5125 [RSC publishing group], 2011.

101. Plasmid DNA linearization in the antibacterial Action of a new Fluorescent Ag Nanoparticle-Paracetametol Dimer composite. Sahoo A.K, Md Palashuddin Sk, Ghosh SS and Chattopadhyay A. Nanoscale, 3(10), 4226-4233 [RSC publishing group], 2011.

102. Induction of apoptosis in cancer cells at low silver nanoparticle concentrations using chitosan nanocarrier. Sanpui P, Chattopadhyay A and Ghosh SS. ACS Applied Materials & Interfaces, 3(2), 218-228 [ACS publishing group], 2011.

103.Synthesis and characterization of a novel chitosan based E. coli cytosine deaminase nanocomposite for potential application in prodrug enzyme therapy. Yata VK and Ghosh SS. Biotechnology Letters, 33(1), 153-157 [Springer publishing group], 2011.

104. Interaction studies of E. coli uracil phosphoribosyltransferase with 5-fluorouracil for potent anticancer activity. Yata V.K, Sen K., Kumar M.V.S. and Ghosh SS. Medicinal Chemistry Research, DOI: 10.1007/s00044-011-9627-z [Springer publishing group], 2011.

105.Investigating fluorescence quenching of ZnS quantum dots by silver nanoparticles. Jaiswal A, Sanpui P, Chattopadhyay A and Ghosh SS. Plasmonics, 6, 125–132 [Springer publishing group], 2010.

106.Plasmonic signatures in the composite crystals of gold nanoparticles and p-Hydroxyacetanilide (Paracetamol). Das S, Sahoo A.K, Ghosh SS and Chattopadhyay A. Langmuir, 26(20), 15714–15717 [ACS publishing group], 2010.

107. Incorporation of gene therapy vector in Chitosan stabilized Mn2+-doped ZnS Quantum. Sanpui P, Pandey S.B, Chattopadhyay A and Ghosh SS. Material Letters, 64 (22), 2534-2537 [Elsevier publishing group], 2010.

108.Signaling gene cascade in silver nanoparticle induced apoptosis. P. Gopinath, Gogoi S. K, Sanpui, P, Paul, A, Chattopadhyay A, Ghosh SS. Colloids Surface B Biointerfaces. 77(2), 240-5 [Elsevier publishing group], 2010.

109.Heightened reactive oxygen species generation in the antimicrobial activity of a three component iodinated chitosan-silver nanoparticle composite. Banerjee M, Mallick S, Paul A, Chattopadhyay A, Ghosh SS. Langmuir, 26(8), 5901-5908 [ACS publishing group], 2010.

110. Understanding apoptotic signaling pathways in cytosine deaminase-uracil phosphoribosyl transferase-mediated suicide gene therapy in vitro. P. Gopinath and Ghosh SS. Molecular and Cellular Biochemistry, 324(1-2), 21-29 [Springer publishing group], 2009.

111.Green fluorescent protein for in situ synthesis of highly uniform Au nanoparticles and monitoring protein denaturation. Sanpui P, Pandey SB, Ghosh SS, Chattopadhyay A. Journal of Colloid Interface Science, 326(1), 129-137 [Elsevier publishing group], 2008.

112.The antibacterial properties of a novel chitosan-Ag-nanoparticle composite. Sanpui P, Murugadoss A, Prasad, P.V, Ghosh SS, Chattopadhyay A. International Journal of Food Microbiology, 24(2), 142-146 [Elsevier publishing group], 2008.

113.Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy. P. Gopinath, Gogoi S. K, Chattopadhyay A and Ghosh SS. Nanotechnology, 19(7), 075104. [IOP Science publishing group], 2008.

114. Implication of functional activity for determining therapeutic efficacy of suicide genes in vitro. P. Gopinath and Ghosh SS. Biotechnology Letters, 30 (11), 1913-1921 [Springer publishing group], 2008.

115. Apoptotic induction with bifunctional E.coli cytosine deaminase-uracil phosphoribosyltransferase mediated suicide gene therapy is synergized by curcumin treatment in vitro. P. Gopinath and Ghosh SS. Molecular Biotechnology, 39(1), 39-48 [Springer publishing group], 2008.

116. Monitoring green fluorescent protein for functional delivery of E. coli cytosine deaminase suicide gene and the effect of curcumin in vitro. P. Gopinath and Ghosh SS. Gene Therapy and Molecular Biology, 11, 219-228 [GTMB publishing group], 2007.

117. Evaporation-induced patterns from droplets containing motile and nonmotile bacteria. Nellimoottil T. T, Rao P. N, Ghosh SS, Chattopadhyay A. Langmuir, 23 (17), 8655-8658 [ACS publishing group], 2007.

118. Reply to comment on evaporation-induced patterns from droplets containing motile and nonmotile bacteria. Nellimoottil T. T, Rao P. N, Ghosh SS, Chattopadhyay A. Langmuir, 23, 11942-11942 [ACS publishing group], 2007.

119. Adenoviral vectors: A promising tool for gene therapy. Ghosh SS, P. Gopinath and Ramesh A. Applied Biochemistry and Biotechnology, 133 (1), 9-29 [Springer publishing group], 2006.

120. Green fluorescent protein-expressing Escherichia coli as a model system for investigating the antimicrobial activities of silver nanoparticles. Gogoi S K, P. Gopinath, Paul A, Ramesh A, Ghosh SS and Chattopadhyay A. Langmuir, 22, 9322-9328 [ACS publishing group], 2006.

121. Role of cysteine residues in the function of human UDP Glucuronosyltransferase isoform 1A1 (UGT1A1). Ghosh SS, Lu Y, Lee W, Wang X, Guha C, Roy-Chowdhury J and Roy-Chowdhury N. Biochemical Journal, 15 (392), 685-692, 2005.

122. Hepatocyte transplantation and liver-directed gene therapy. Guha C, Ghosh SS, Lee SW, Roy-Chowdhury N and Roy-Chowdhury J. Molecular Pathogenesis of Cholestasis, 340-360, 2004.

123. Hepatocyte-targeted delivery of Sleeping Beauty mediates efficient gene transfer in vivo. Kren BT, Ghosh SS, Linehan CL, Roy Chowdhury N, Hackett PB, Roy Chowdhury J, Steer CJ. Gene Therapy and Molecular Biology, 7, 229-238, 2003.

124. Using new gene delivery systems to advance HIV gene therapy. Strayer DS, Goldstein H, Cordelier P, Ghosh SS, Strayer M.S, Pettoello- Mantovani M, Roy Chowdhury J. Clinical and Applied Immunology Reviews, 3 (4-5), 247-259, 2003.

125. Molecular therapies for viral hepatitis. Guha C, Shah SJ, Ghosh SS, Roy Chowdhury N and Roy Chowdhury J. BioDrugs, 17 (2): 81-91, 2003.

126. Critical role of cysteine residues in human UGT1A1 in bilirubin glucuronidation. Ghosh SS, SW Lee, Roy Chowdhury J and Roy Chowdhury N. Hepatology, 38, 384, 2003

127. A non-immunogeneic adenoviral vector, co-expressing CTLA4Ig and bilirubin-uridine- diphospoglucuronate-glucuronosyl transferase permits long-term, repeatable transgene expression in the GUNN rat model of Crigler-Najjar syndrome. Thummala NR, Ghosh SS, Lee S.W, Horwitz M.S, Reddy B, Davidson A, Roy Chowdhury J, Roy Chowdhury N. Gene Therapy. 9(15), 981-990, 2002.

128. A novel intronic mutation results in the use of a cryptic splice acceptor site within the coding region of UGT1A1, causing Crigler-Najjar Syndrome Type 1. Sappal BS, Ghosh SS, Shneider B, Kadakol A, Roy Chowdhury J and Roy Chowdhury N. Molecular Genetics and Metabolism, 75(2), 134-142, 2002.

129. Durability of Transgene Expression and Vector Integration: Recombinant SV40-Derived Gene Therapy Vectors. Strayer DS, Branco F, Zern MA, Yam P, Calarota SA, Nichols CN, Zaia JA, Rossi J, H Li, Parashar B, Ghosh SS, and Roy Chowdhury J. Molecular Therapy, 6(2), 227, 2002.

130.Homodimerization of human- uridinediphosphoglucuronateglucuronosyl-transferase-1 (UGT1A1) and its functional implications. Ghosh SS, Sappal B.S, Kalpana GV, Lee SW, Roy Chowdhury J and Roy Chowdhury N. Journal of Biological Chemistry, 276 (45), 42108-42115, 2001.

131. Amplification of Engrafted Hepatocytes by Preparative Manipulation of the Host Liver. Guha C, Deb N.J, Sappal B.S, Ghosh S.S, Roy Chowdhury N and Roy Chowdhury J. Artificial Organs, 25 (7), 522-528 2001.

132. Recombinant SV40 vector-mediated transfer of beta-glucuronidase gene into mucopolysaccharidosis type VII mice. Kawashita Y, Caton M, Ghosh SS, Takahashi M, Roy Chowdhury N, Okuyama T, Guha C, Whitley CB, Strayer DS, Roy Chowdhury J. Molecular Therapy, 3, 5 2001.

133. Liver directed gene therapy; promises, problems and prospects at the turn of the century. Ghosh SS, Takahashi M, Parashar B, Thummala NR, Roy Chowdhury N and Roy Chowdhury J. The Journal of Hepatology, 32, 238-252, 2000.

134. Gene therapy for hyperbilirubinemic conditions. Roy Chowdhury N, Kadakol A, Sappal B.S, Ghosh SS, Lee SW and Roy Chowdhury J. Journal of Perinatology, 21, S114-118, 2001.

135.A non-immunogenic adenoviral vector, coexpressing CTLA4Ig and bilurubin-UDP-glucuronosyltransferase (UGT1A1) permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome type 1. Thummala NR, Ghosh SS, Lee SW, Caton M, Davidson A, Reddy B. Hepatology, 34 (4), 357A-356A, 2001.

136. Interaction of. Crigler-Najjar-type and Gilbert’s-type mutations causes intermediate degrees of hyperbilirubinemia and may cause kernicterus. Kadakol A, Sappal B.S, Ghosh SS, Lowenheim M, Chowdhury A, Chowdhury S, Santra A, Arias IM, Roy Chowdhury J, and Roy Chowdhury N. Journal of Medical Genetics, 38(4), 244-249, 2001.

137. Inherited Disorders of bilirubin Metabolism Kadakol A, Sappal BS, Ghosh SS, Roy Chowdhury J and Roy Chowdhury N. Gastroenterology Today, 4, 1, 2000.

138. Comparison of currently existing methods of gene transfer to the liver and prospects of liver-directed gene therapy. Parashar B, Ghosh SS, Takahasi M, Roy Chowdhury N, Roy Chowdhury J. Gastroenterology Today, 4, (1), 2000.

139. Genetic Lesions of Bilirubin Uridinediphospho-glucuronate Glucuronosyltransferase Causing Crigler-Najjar and Gilbert's Syndromes: Correlation of Genotype to Phenotype. Kadakol A, Ghosh SS, Sappal BS, Sharma G, Roy Chowdhury J and Roy Chowdhury N. Human Mutation, 16, 297-306, 2000.

140. Hepatocyte transplantation at the turn of the century Prospects and remaining hurdles Kadakol A, Takahashi M, Parashar B, Guha C, Ghosh SS, Roy Chowdhury N and Roy Chowdhury J. Organ Biology, 6, 4, 43-51,1999.

141. Recombinant Simian virus 40 vectors integrate into host genome, and permit efficient, long-term and repeatable gene transfer to the liver in vivo. Ghosh SS, Kadakol A, Sauter BV, Takahashi M, Roy Chowdhury N and Roy Chowdhury J. Hepatology, 30,298A, 1999.

142. Molecular karyotyping of Indian Leishmania donovani strains using nuclear DNA probes. Ghosh SS, Mukherjee S, Adhya S. Journal of Biosciences, 23, 247- 254, 1998.

143. Role of a membrane-associated serine esterase in the oxidant activation of phospholipase A2 by t-butyl hydroperoxide. Chakraborti S, Michael JR, Gurtner GH, Ghosh SS, Dutta G, Merker A. Biochemical Journal, 292, 585- 589, 1993.

144. Enzymatic amplification of mini-exon-derived RNA gene spacers of Leishmania donovani; primers and probes for DNA diagnosis. Hassan MQ, Ghosh A, Ghosh SS, Gupta M, Basu D, Mallik KK and Adhya S. Parasitology, 107, 509- 517,1993

List of patents obtained / applied:

Title of the invention: A device with integrated methods for reverse transcription polymerase chain reaction (RTPCR) and/or DNA/Protein array based analyses (2015). Inventors: Chattopadhyay A, Sailapu SK, Dutta D, Sahoo AK, Ghosh SS. Indian Patent Application No. 1259/KOL/2015 dated 09.12.2015.
Title of the invention: Wirelessly Operated Led Device for Photodynamic Therapy and Subsequent Monitoring of Therapeutic Success. Inventors: Chattopadhyay A, Sailapu SK, Dutta D, Ghosh SS. Indian Patent Application No. 201731031603.
Title of the invention: A device with integrated methods for reverse transcription polymerase chain reaction (RT-PCR) and/or DNA/protein array based analyses (2016). Inventors: Chattopadhyay A, Sailapu SK, Dutta D, Sahoo AK, Ghosh SS. International (USA) Patent Publication Number: WO 2017098521 A1

4. Title of the invention: Glutathione-S-transferase – nanoconjugate based FET biosensor for detection of cancer (2018). Inventors: Barman U, Ghosh SS and Paily R P. Indian Patent Application No. 201831031884.

5. Title of the invention: An ultra-low voltage operated organic field effect transistor (OFET) based bio-sensing system and a method for fabricating the same (2018). Inventors: Iyer PK, Dey A, Singh A, Dutta D, Ghosh SS. Indian Patent Application No. 201831000478.

6. Title of the invention: A composition for filtration of microorganism and heavy metals and process thereof (2018). Inventors: Das M, Goswami U, Ghosh SS, Chattopadhyay A. Indian Patent Application No. 201831016639.

7. Title of the invention: Bimetallic nanocomposite based Wound Healing System and method of manufacture Thereof (2019). Inventors: Chattopadhyay A, Ghosh SS, Das M, Goswami U, Kandimalla R, Kalita S Indian Patent Application No. 201931014175.

Title of the invention: An ultra-low voltage operated organic field effect transistor (OFET) based bio-sensing system and a method for fabricating the same (2020). Inventors: Iyer PK, Dey A, Singh A, Dutta D, Ghosh SS. PCT application/ international application filed.

Technology Transfer (ToT):

ToT on “BACTERIA DETECTION METHOD” between Indian Institute of Technology Guwahati and M/s R.R Animal Health Care Limited Hyderabad-50006, was commended based on the joint innovation of Prof. PK Iyer and Prof. SS Ghosh Groups.

Outreach activity in COVID Pandemic:

In response to a request from the National Disaster Management (NDM) Guwahati Assam, the DBT Programme Support Facility (Prof. S. S Ghosh’s group) along with the Centre for Nanotechnology (Prof. P. K. Iyer’s group), IITG, have developed the COVID detection kits as per the protocols of WHO and CDC guidelines. The company M/s R R Animal Health Care Limited was also involved as a partner in this entire development and scale up processes for viral transport media (VTM), viral RNA extraction kit and Real Time PCR kit. The kits were authenticated on patient samples at the COVID testing laboratory of Guwahati Medical College and Hospital (GMCH) and validated by ICMR, India. The low cost indigenous kits were supplied to the Government of Assam through NDM. This non-profitable work led to establish of a start-up by M/s R R Animal Health Care Limited at the Research Park of IITG. The effort was acknowledged by Honorable Health Minster of India, Higher Education Minister of India, and the Prime Minister’s Office.

PhD Students:

PhD Student Guided/Completed:

SL. No.	Name	Title of the Thesis	Period		Current Address
SL. No.	Name	Title of the Thesis	From	To	Current Address
1.	Dr. P. Gopinath	Prodrug gene therapy vectors in combination therapies	January 2004	August 2008	Associate Professor, Department of Biotechnology, IIT Roorkee, joined 2011
2.	Dr. Pallab Sanpui (Joint with Prof. A. Chattopadhyay)	Therapeutic implications of polymer-metal nanoparticle composites	July 2005	January 2011	Assistant Professor, BITS Pilani (Dubai), joined 2017
3.	Dr. Vinod Kr. Yata	Suicide Enzymes: Purification, Characterization and Encapsulation for Therapeutic Implications	January 2008	March 2012	Research Associate at National Dairy Research Institute (NDRI), Haryana. since 2017
4.	Dr. Shilpa Sharma (Joint with Prof. A. Chattopadhyay)	Metal nanoparticles and nanocomposites as antimicrobial and anticancer agents	July 2008	March 2013	Assistant Professor, Division of Biotechnology, Netaji Subhas Institute of Technology (NSIT), Delhi, since 2014
5.	Dr. Amit Jaiswal (Joint with Prof. A. Chattopadhyay)	Fluorescent Nanomaterials for Biological Applications	July 2010	September 2013	Assistant Professor, School of Basic Sciences, IIT Mandi, joined 2014
6.	Dr. V. Kohila	Genetic engineering approaches to alter substrate specificity of suicide genes	July 2008	March 2014	Assistant Professor, Department of Biotechnology, NIT Warangal, joined 2013
7.	Dr. Subhamoy Banerjee	Signaling molecules in combination therapy	January 2009	April 2014	Assistant Professor, School of life sciences, B.S. Abdur Rahman University, joined 2016
8.	Dr. S. Chokalingam	Molecular approaches for development of efficient suicide gene therapy	July 2008	June 2014	Assistant Professor NIT Warangal, joined 2019
9.	Dr. Nidhi Chaubey	Molecular Cloning, Expression, Purification and Functional Implications of Recombinant Cytokines	January 2009	June 2014	-
10.	Dr. Mithun Chakraborty (Joint with Prof. P. Goswami)	Molecular Characterization of Broad Substrate Specific Alcohol Oxidase from Aspergillus terreus MTCC 6324	July 2009	August 2014	Assistant Professor, Department of Biotechnology Chandigarh University, Mohali, joined 2016
11.	Dr. Amaresh Kr. Sahoo (Joint with Prof. A. Chattopadhyay)	Drug Based Nanocomposites in Biological Applications	July 2009	March 2015	Assistant Professor, Indian Institute of Information Technology (IIIT) Allahabad, joined 2016
12.	Dr. Archita Ghoshal	Cell Surface Targeted Recombinant Signaling Molecules	July 2011	June 2016	Postdoctoral Fellow, ICGEB India, since June 2019
13.	Dr. N. Sharmila (Joint with Prof. L. Sahoo)	Functional Characterizations of Plant Uracil Phosphoribosyltransferase and Phytaspase for their Potential in Cancer Therapy	July 2011	April 2017	Postdoctoral Fellow, University of Saskatchewan, Canada, since December 2018
14.	Dr. Asif Raza	Connexin-43 Mediated Communication in Cancer Gene Therapy	July 2012	November 2017	Postdoctoral Fellow, Penn State College of Medicine, Hershey, USA, since June 2018
15	Dr. Bandhan Chatterjee (Joint with Prof. A. Chattopadhyay)	Developing Gold nanocluster Based Cancer Theranostics	July 2012	June 2018	Postdoctoral Fellow, Translational Health Science and Technology Institute (thsti), India
16.	Dr. Deepanjalee Dutta (Joint with Prof. A. Chattopadhyay)	Multifunctional Nanomaterials for Theranostic Applications	July 2013	August 2018	Postdoctoral Fellow, University of Edinburgh, UK, since October 2018
17.	Dr. Upashi Goswami (Joint with Prof. A. Chattopadhyay)	Luminescent Gold and Copper Nanoclusters for Theranostic Applications	July 2012	October 2018	DST INSPIRE Faculty IISC, Bangalore since April 2019
18.	Dr. Ujjwol Barman (Joint with Prof. Roy P. Pailey)	Field Effect Transistor Based Biosensor for Detection of Glutathione	July 2013	April 2019	Joined as an Assistant Professor at KIIT Bhubaneswar in June 2019
19.	Dr. Neha Arora	Understanding the Potential of Recombinant PTEN in Cancer Therapeutics	July 2013	January 2019	Postdoctoral Researcher in MD Anderson, USA, since October 2019
20	Dr. Madhumita Das (Joint with Prof. A. Chattopadhyay)	Copper Based Nanomaterials for Potential Biomedical Applications	July 2014	November 2019	Head, Department of Pathology, GNRC Hospital, Guwahati
21.	Bidkar Anil Parsram	Multifaceted Approaches for Cancer Therapeutics	July 2014	December 2019	Postdoctoral Fellow, University of California San Francisco (UCSF) since December 2020
22	Tammana Bhuyan (Joint with Prof.. D. Bandhyopadhyay)	Controlled Movements of Biomotors and Microfluidics	July 2014	June 2020	Thesis Defended in June 2020
23	Srirupa Bhattacharyya	Unfolding Therapeutic Potential of TNF alpha	July 2015	December 2020	Joining Harvard Medical School as Postdoctoral Fellow in 2021

Current PhD students:

SL. No.	Name	Title of the Thesis or Research Area	Period		Status/ Category
SL. No.	Name	Title of the Thesis or Research Area	From	To	Status/ Category
1.	Rajib Shome	EMT Dynamics	July 2016	Ongoing	Regular
2.	Anitha T Simon (Joint with Prof. A. Chattopadhyay)	Nanocarriers for Drug Delivery	July 2016	Ongoing	Regular (Project sponsored)
3.	Muktashree Saha	Exosomes-mediated Therapy	July 2017	Ongoing	Regular
4.	Debashree Debasmita (Joint with Prof. A. Chattopadhyay)	Nanobiotechnology in Sensing	July 2017	Ongoing	Regular
5.	Konika Chowdhury (Joint with Prof. A. Chattopadhyay)	Cancer Immunotherapy	July 2018	Ongoing	Regular
6.	Plaboni Sen	Molecular Signalling in cancer	July 2018	-	Regular
7.	Arupam Patra (Joint with Prof. Gurvinder Saini)	Fungal Metabolites in Cancer Therapy	July 2018	-	Regular
8.	Niraj Kr. Prasad (Joint with Prof. AK Dalal, Mech. Engg.)	Microfluidics on Biology	July 2019	-	Regular
9.	Shilpi Ghosh	Molecular Signalling in Cancer	July 2019	-	Regular
10.	K. Thirukumaran	Course Work	July 2020	-	Regular
11.	Hirok Joyti Roy (Joint with Prof. P. K. Iyer)	Course Work	July 2020	-	Regular
12.	Sayantani Mukhopadhyay (Joint with Prof. P. K. Iyer)	Course work	July 2020	-	Regular

M. Tech Students:

· Number of students completed their M.Tech Projects: 10

· Current Student: 01

B .Tech Students:

· Number of students completed B.Tech projects: 38

· Current student: 01

Indian Institute of Technology Guwahati	© 2013 Department of Biotechnology
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