Our research is primarily focused on the following aspects:
1. The coordination of nitric oxide (NO) to transition metal ions and its activation as
various biological and physiological reactivity of nitric oxide are attributed to the
formation of nitrosyl complexes of metalloproteins.
2. The study of small molecule models for reductase enzymes which catalyze the
reduction of nitrite to nitric oxide or nitrous oxide.
3. Metal -nitrosyl adducts presumably play important roles in nitrosation reactions
of various thiols to give S-nitrosothils which are proposed as the carriers for nitric
oxide equivalents in cellular systems. We have been involved in studying the reduction
of copper(II) centers by nitric oxide leading to ligand nitrosation in synthetic model systems.
4. Nitric oxide behaves as cytotoxic effector/or pathogenic mediator when produced at high
concentration because of formation of secondary intermediates like peroxynitrite or
nitrogen dioxide. The formation of these intermediates from nitric oxide requires the presence
of oxidants like superoxide, peroxide and transition metal ions. We have been involved to study
the role of transition metal ions for generation, stabilization, activation for substrate oxidation.
of peroxynitrite.
5. Oxo transfer from nitrogen dioxide to nitrito group in various metal complex.
6. Development of fluorescene based nitric oxide sensors as efficient probe for real-time detection.