![top](21_files/top.png)
The direct conversion of various carboxylic acids, that include sterically hindered amino acids and di-peptides, to O-benzyl hydroxamates is demonstrated using sulfonate esters of benzotriazoles under ambient and milder conditions without significant racemization. This simple and efficient protocol is extended to the synthesis of O-benzyl hydroxamates, using in situ generated solid supported TsOBt to facilitate the recovery and re-usability of HOBt and to render the isolation of the products easier. Such in situ generation and further application of a coupling reagent is novel and industrially important.
![Graphical abstract Graphical abstract: Synthesis of O-benzyl hydroxamates employing the sulfonate esters of N-hydroxybenzotriazole](21_files/GA.gif)
![bottom](21_files/bottom.png)
Fetching data from CrossRef. This may take some time to load.
![Please wait while forward links loads Please wait while forward links loads](21_files/Ajax-GA-Loader.gif)
![Loading Related Content Loading Related Content](21_files/Ajax-GA-Loader.gif)