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The synthesis of peptide alcohols from peptides bearing C-terminal amide using β-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.
![Graphical abstract Graphical abstract: Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide](26_files/GA.gif)
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