');

Communication

You have full text access to this content

Switch Peptides In Statu Nascendi: Induction of Conformational Transitions Relevant to Degenerative Diseases†

  1. Manfred Mutter Prof.,
  2. Arunan Chandravarkar Dr.,
  3. Christine Boyat Dr.,
  4. John Lopez Dr.,
  5. Sonia Dos Santos Dipl.-Chem.,
  6. Bhubaneswar Mandal Dipl.-Chem.,
  7. Richard Mimna Dipl.-Chem.,
  8. Karine Murat Dipl.-Chem.,
  9. Luc Patiny Dr.,
  10. Lydiane Saucède Dipl.-Chem. and
  11. Gabriele Tuchscherer Dr.

Article first published online: 9 AUG 2004

DOI: 10.1002/anie.200454045

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 43, Issue 32, pages 4172–4178, August 13, 2004


Additional Information(Show All)

How to CiteAuthor InformationPublication History

How to Cite

Mutter, M., Chandravarkar, A., Boyat, C., Lopez, J., Dos Santos, S., Mandal, B., Mimna, R., Murat, K., Patiny, L., Saucède, L. and Tuchscherer, G. (2004), Switch Peptides In Statu Nascendi: Induction of Conformational Transitions Relevant to Degenerative Diseases. Angew. Chem. Int. Ed., 43: 4172–4178. doi: 10.1002/anie.200454045

Author Information

  1. Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology, EPFL-BCH, 1015 Lausanne, Switzerland, Fax: (+41) 21-693-9415

  1. †

    This work was supported by the Swiss National Science Foundation. The Ncap peptidomimetic was a generous gift from Prof. Klaus Müller, Hoffman-La Roche, Basel, Switzerland.

Publication History

  1. Issue published online: 9 AUG 2004
  2. Article first published online: 9 AUG 2004
  3. Manuscript Received: 17 FEB 2004
View Full Article (HTML) Enhanced Article (HTML) Get PDF (304K)Get PDF (304K)

Keywords:

  • Alzheimer’s disease;
  • circular dichroism;
  • protein folding;
  • protein structures;
  • switch peptides
Thumbnail image of graphical abstract

A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying molecular processes (see scheme) that play a key role, for example, in early events of Alzheimer's disease.

View Full Article (HTML) Enhanced Article (HTML) Get PDF (304K)Get PDF (304K)