Laboratory for
Stem Cell Engineering and Regenerative Medicine
Welcome to SCERM LAB
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Research Areas
- Generation of transgene-free induced Pluripotent Stem Cells (iPSCs) using non-integrative approaches.
- Understanding the molecular mechanisms of cell reprogramming.
- Enhancing the efficiency and the kinetics of cell reprogramming.
- Generation of functional cardiomyocytes from either iPSCs or by direct reprogramming of somatic cells using integrative and non-integrative approaches.
- Generation of functional insulin producing β-cells from either iPSCs or by direct reprogramming of somatic cells using integrative and non-integrative approaches.
- Design and development of novel non-integrating vectors for iPSC generation.
- Investigating the role of core stem cell-specific transcription factors governing stem cell self-renewal, pluripotency and differentiation.
- Elucidating the epigenetic mechanisms governing stem cell self-renewal, pluripotency and differentiation.
- Identifying the crucial differences between normal stem cells vs cancer stem cells.
- Genome editing in pluripotent stem cells.
- Understanding stem cell heterogeneity.