Bioorganic Chemistry Research Laboratory @ IITG
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Bioorganic Chemistry Research Laboratory @ IITG
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Research Output before joining IIT Guwahati

2013

22.   Bhabak, K. P.; Hauser, A.; Redmer, S.; Banhart, S.; Heuer, D.; Arenz, C.* "Development of a Novel FRET Probe for the Real-Time Determination of     
        Ceramidase Activity"  ChemBioChem   2013,   14,   1049-1052.
        (This work has been featured on the Cover Page of the Journal)

21.    Bhabak, K. P.; Arenz, C.* "Novel Drugs Targeting Sphingolipid Metabolism", In Sphingolipids: Basic Science and Drug Development In  Handbook Exp.
         Pharmacol. Eds. Gulbins, E.; Petrache, I., Springer-Verlag Wien, 2013215,   p187-196 (Book Chapter).

20.    Bhabak, K. P.; Bhowmick, D.; Mugesh, G.* "Synthetic glutathione peroxidase mimics: Effect of nucleophilicity of the aryl thiol cofactor on the antioxidant
         activity"  Ind. J. Chem. A   2013,   52A,   1019-1025.

19.    Bhabak, K. P.; Kleuser, B.; Huwiler, A.; Arenz, C.* "Effective Inhibition of Acid and Neutral Ceramidases by Novel B-13 and LCL-464 Analogues"
     Bioorg. Med. Chem.   2013,   21,   874-882.

2012

18.    Bhabak, K. P.; Arenz, C.*"Novel Amide- and Sulfonamide-based B-13 and D-MAPP Analogues: Effect of Aromatic Substituents on the Inhibition of Acid and
         Neutral Ceramidases" Bioorg. Med. Chem.   2012,   20,   6162-6170.

17.    Bhabak, K. P.; Proksch, D.; Redmer, S.; Arenz, C.*"Novel Fluorescent Ceramide Derivatives for Probing Ceramidase Substrate Specificity"
       Bioorg. Med. Chem.   2012,   20,   6154-6161.

16.   Bhabak, K. P.;* Debasish Bhowmick "Synthesis and Structural Characterization of some Trisulfide Analogues of Thiourea-based Antithyroid Drugs."
      J. Mol. Struct.   20121022,   16-24.

15.    Bhabak, K. P.; Mugesh, G.* "Synthetic Mimics of Selenoproteins" In Selenoproteins and Mimics Eds. Liu, J.; Luo, G., Zhejiang University Press,
         Hangzhou and Springer-Verlag Berlin Heidelberg  2012,  p207-221 (Book Chapter)

2011

14.    Bhabak, K. P.; Mugesh, G.* "Gold(I)-Selenolate Complexes: Synthesis, Characterization and Ligand Exchange Reactions"
          J. Chem. Sci.   2011, 123,   783-789.

13.   Bhabak, K. P.; Satheeshkumar, K.; Jayavelu, S.; Mugesh, G.* "Inhibition of Peroxynitrite- and Peroxidase-mediated Protein Tyrosine Nitration by
        Imidazole-based Thiourea and Selenourea Derivatives" Org. Biomol. Chem.   20119,   7343-7350.

12.    Bhabak, K. P.; Mugesh, G.* "Synthesis and Characterization of Some Gold(I)-Thiolate Complexes Having N-Methylimidazole Moiety"
        Ind. J. Chem. 2011,   50A,   1303-1307.

11.    Roy, G.; Bhabak, K. P.; Mugesh, G.* "Interactions of Antithyroid Drugs and their Analogues with Halogens and their Biological Implications"
          Crystal Growth & Design,   2011, 11,   2279-2286.

10.    Bhabak, K. P.; Vernekar, A. A.; Jakka, S. R.; Roy, G.; Mugesh, G.* "Mechanistic Investigations on the Efficient Catalytic Decomposition of Peroxynitrite by
         Ebselen Analogues" Org. Biomol. Chem.  20119,   5193-5200.

09.    Bhabak, K. P.; Bhuyan, B. J.; Mugesh, G.* "Bioinorganic and Medicinal Chemistry: Aspects of Gold(I)-Protein Complexes."
        Dalton Trans.  201140,   2099-2111.

2010

08.    Bhabak, K. P.; Mugesh, G.* "Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants."
        Acc. Chem. Res.  201043,   1408-1419.
           (This work has been featured on the Cover Page of the Journal)

07.   Bhabak, K. P.; Mugesh, G.* "Inhibition of Peroxidase-catalyzed Protein Tyrosine Nitration by Antithyroid Drugs and their Analogues."
       Inorg. Chim. Acta  2010363,   2812-2818.

06.    Bhabak, K. P.; Mugesh, G.* "Antithyroid Drugs and their Analogues Protect Against Peroxynitrite-Mediated Protein Tyrosine Nitration -A Mechanistic Study."
      Chem. Eur. J.  201016,   1175-1185.
        (This work has been featured on the Cover Page of the Journal)

2009

05.    Bhabak, K. P.; Mugesh, G.* "Synthesis and Structure-Activity Correlation Studies of Secondary and Tertiary Amine-based Glutathione Peroxidase Mimics."
      Chem. Eur. J.   200915,   9846-9854.

04.   Bhabak. K. P.; Mugesh, G.* "A Synthetic Model for the Inhibition of Glutathione Peroxidase by Antiarthritic Gold Compounds."
      Inorg. Chem.   200948,   2449-2455.

03.    Bhabak, K. P.; Mugesh, G.* "Amide-Based Glutathione Peroxidase Mimics: Effect of Secondary and Tertiary Amide Substituents on Antioxidant Activity."
        Chem. Asian J.   20094,   974-983.

2008

02.   Bhabak, K. P.; Mugesh, G.* "A Simple and Efficient Strategy To Enhance the Antioxidant Activities of Amino-Substituted Glutathione Peroxidase Mimics."
          Chem. Eur. J.   200814,   8640-8651.

2007

01.   Bhabak, K. P.; Mugesh, G.* "Synthesis, Characterization and Antioxidant Activity of Some Ebselen Analogues."
    Chem. Eur. J.   200713,   4594-4601.


Conferences/Posters/Presentations

17. Bhabak, K. P. (2023): Delivered an Invited Lecture in the Short Term Training Programme on "DRINKING WATER QUALITY AND PUBLIC HEALTH (PS21B)"  at NITTTR, Kolkata during 22 May - 02 June, 2023.

16. Bhabak, K. P. (2023): Delivered an Invited Lecture in the international symposium "Emerging Trends in Chemical Sciences-2023 (ETCS-2023)" at NEHU, Shillong, Meghalaya, during 2-4 March, 2023.

15. Bhabak, K. P. (2022): Delivered an Invited Leture in the international symposium "Frontiers in Chemical Sciences-2022 (FICS-2022)" at IIT Guwahati during 2-4 December, 2022.

14. Bhabak, K. P. (2022): Delivered a Departmental Lecture at the Department of Chemistry, IIT Madras during 23 September, 2022.

13. Bhabak, K. P. (2022): Delivered an Invited Lecture at CSIR-Central Leather Research Institute (CLRI) on the occasion of the "Celebration of 75th Foundation Day of the Institute" during 22 September, 2022.

12. Bhabak, K. P. (2020): Delivered an Invited Lecture in "Diversity in Catalytic Approaches" at National Institute of Technology, Manipur (NIT Manipur) during 27-31 October, 2020.

11.  Bhabak, K. P. (2017): Participated and presented a Poster in "INSPIRE Faculty Monitoring-cum-Interaction Meet" in the subject area of Chemical Sciences & Material Sciences at the KIIT University, Bhubaneswar, Odisha during 16-17th Jan 2017.

10.  Bhabak, K. P. (2016): Invited lecture in KIC TEQIP Short term Course on 'Recent Trends in Catalysis' in Department of Chemistry, IIT Guwahati during 13-14th May, 2016.

09. Bhabak, K. P. (2015): Participated and presented a Poster in the National Conference "New Frontiers in Chemistry -- From Fundamentals to Applications" (NFCFA2015)" in Department of Chemistry, BITS Pilani KK Birla Goa Campus during 18-19 December, 2015.

08. Bhabak, K. P. (2015): Participated and presented a Poster in "Networking-Cum-Discussion Meet" for existing INSPIRE Faculty Awardees at Tezpur University, Tezpur, Assam, India during 20-21st March, 2015.

07. Bhabak, K. P. (2014): Participated and presented a Poster in "2nd International Symposium on Emerging Trends in Chemical and Pharmaceutical Sciences and Pharma. Chem. Expo-2014" at Indian Institute of Chemical Technology (IICT), Hyderabad, India during October 15-17, 2014.

06. Bhabak, K. P. (2014): Participated in "16th CRSI National Symposium in Chemistry (NSC-16)" in Department of Chemistry, Indian Institute of Technology Bombay (IITB), India during 7-9th Feb 2014.

05.  Bhabak, K. P. (2013): "Real-Time Determination of Ceramidase Activity by Novel FRET-based Substrate Analogues" participated and delivered Oral Presentation in the UGC-sponsored National Symposium on "Current Trends in Chemistry" in Department of Chemistry, Sripat Singh College, Murshidabad, West Bengal, India during 23-24th Dec, 2013.

04.  Bhabak, K. P.; Arenz, C. (2012): "Development of novel fluorescent ceramide analogues for the inhibition of ceramidase activity" Presented Poster on Challenges in Bioorganic & Organic Medicinal Chemistry at 13th Tetrahedron Symposium on 26-29 June 2012, Amsterdam, Netherlands.

03.  Bhabak, K. P.; Arenz, C. (2011): "Inhibition of Ceramidase Activity by Novel B-13 Analogues" Presented a Poster at the "1st Bonn Humboldt Award Winners" Forum of the Alexander von Humboldt Foundation" at Bonn, GERMANY.

02. Bhabak, K. P.; Mugesh, G. (2008): "Antithyroid Drugs and Related Compounds Effectively Protect Against Peroxynitrite-mediated and Peroxidase-catalyzed Nitration and Oxidation Reactions" Presented a Poster at the "10th CRSI National Symposium in Chemistry" at Indian Institute of Science (IISc), Bangalore, INDIA.

01.  Bhabak, K. P.; Mugesh, G. (2007): "Antithyroid Drugs and Related Compounds Effectively Protect against Heme-Peroxidase-catalyzed Nitration Reactions" Presented a Poster at the "Modern Trends in Inorganic Chemistry-XII (MTIC-XII) at Indian Institute of Technology (IIT) Madras, INDIA.

Research Output after joining IIT Guwahati
23.    Bhabak, K. P.*; Bhowmick, D. "Synthetic strategies of gold(I)-selenolates from ortho-substituted diaryl diselenides via selenol and selenenyl sulfide intermediates" Inorg. Chim. Acta, 2016, 450, 337-345.
2016
24.    Bhattacherjee, D.; Bhabak, K. P.* "Atom based 3D-QSAR studies on 2,4-dioxopyrimidine-1-carboxamide analogs: Validation of experimental inhibitory potencies towards acid ceramidase"   Eur. J. Pharm. Sci. 2016, 83, 8-18. 
25.    Saha, M.; Vyas, K. M.; Martins, L. M.; Martins, N. M. R.;  Pombeiro, A. J. L.; Mobin, S. M.; Bhattacherjee, D.; Bhabak, K. P.; Mukhopadhyay, S. "Copper (II) tetrazolato complexes: Role in oxidation catalysis and protein binding" Polyhedron, 2017, 132, 53-63.
2017

26.    Bhattacherjee, D.; Basu, C.; Bhardwaj, Q.; Mal, S.; Sahu, S.; Sur, R.; Bhabak, K. P.*   "Design, Synthesis and Anti-Cancer Activities of Benzyl Analogues of Garlic-Derived Diallyl Disulfide (DADS)and the Corresponding Diselenides" ChemistrySelect, 2017, 2, 7399-7406.      

27.     Mandal, P.; Kundu, B. K.; Vyas, K.; Sabu, V.; Helen, A.;  Dhankhar, S. S.; Nagaraja, C. M.; Bhattacherjee, D.; Bhabak, K. P.; Mukhopadhyay, S.*  "Ruthenium(II) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines" Dalton Trans., 2018, 47, 517-527.
2018

28.    Banerjee, K.; Padmavathi, G.; Bhattacherjee, D.; Saha, S.; Kunnumakkara, A. B.; Bhabak, K. P.*  "Potent Anti-proliferative Activities of Organochalcogenocyanates towards Breast Cancer" Org. Biomol. Chem. 2018, 16, 8769-8782.
2019

30.    Bhattacherjee, D.; Sufian, A.;§ Mahato, S. K.;§ Begum, S.;§ Banerjee, K.; De, S.; Srivastava, H. K.* Bhabak, K. P.* "Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H2S release profiles" Chem. Commun. 2019, 55, 13534-13537.
    [§contributed equally to the work]
29.    Malviya, N.; Sonkar, C.; Ganguly, R.; Bhattacherjee, D.; Bhabak, K. P.; Mukhopadhyay, S.* "Novel Approach to Generate Self-Deliverable Anticancer Ru(II) agent in the Self-Reacting Confined Gel Space" ACS Appl. Mater. Interfaces, 2019, 11, 47606-47618.
2020

31.    Mahato, S. K.; Bhattacherjee, D.; Bhabak, K. P.* "Biothiol-triggered Organotrisulfide-based Self-immolative Fluorogenic Donors of Hydrogen Sulfide Enabling Lysosomal Trafficking" Chem. Commun. 202056, 7769-7772.
32.    Sufian, A.; Bhattacherjee, D.; Mishra, T.; Bhabak, K. P.* "Peroxide-responsive boronate ester-coupled turn-on fluorogenic probes: Direct linkers supersede self-immolative linkers for sensing peroxides" Dyes Pigm. 2021191, 109363.
Patents

1.   Bhabak, K. P., Mahato, S. K., Bhattacherjee, D., Barman, P. "Nucleophile-sensitive Fluorogenic Probes and    Donors of Hydrogen Sulfide and Method of Synthesis" Patent Application No: 202231008664; Date: Feb 18, 2022.

2.   Bhabak, K. P. and Banerjee, K. "Heterocyclic Ionic Organoselenium Compounds and Method of Synthesis" Patent Application No: 202131030739; Date: June 08, 2021.
2021

34.    Banerjee, K.; Bhattacherjee, D.; Mahato, S. K.; Sufian, A.; Bhabak, K. P.* "Benzimidazole-and Imidazole-Fused Selenazolium and Selenazinium Selenocyanates: Ionic Organoselenium Compounds with Efficient Peroxide Scavenging Activities" Inorg. Chem.  202160, 12984-12999.
Publications
33.    Ghosh, S.;§Bhattacherjee, D.;§Satpati, P.*; Bhabak, K. P.* "Venetoclax: a promising repurposed drug against SARS-CoV-2 main protease" J. Biomol. Struct. Dyn. 2021 (DOI: https://doi.org/10.1080/07391102.2021.1967786)
[§: Contributed equally to this work]
36.    Banerjee, K.; Bhattacherjee, D.;ξ Raina, K.;ξ Thummer, R. P.*; Bhabak, K. P.* "Benzimidazole-based Ionic and Non-ionic Organoselenium Compounds: Innovative Synthetic Strategies, Structural Characterizations and Preliminary Anti-Proliferative Activities" New J. Chem. 202246, 11910-11926.
[ξ contributed equally to the work]
35.    Mahato, S. K.; Bhattacherjee, D.; Barman, P.; Bhabak, K. P.* "Thioredoxin reductase-triggered fluorogenic donor of hydrogen sulfide: a model study with a symmetrical organopolysulfide probe with turn-on near-infrared fluorescent emission" J. Mater. Chem. B202210, 2183-2193.

37.    Sufian, A.; Bhattacherjee, D.; Barman, P.; Srivastava, A.; Thummer, R. P.; Bhabak, K. P.* "Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence" Chem. Commun. 202258, 7833-7836.
2022

39.    Bhattacherjee, D.; Raina, K.; Mandal, T. K.; Thummer, R. P.*; Bhabak, K. P.* "Targeting Wnt/β-catenin signaling pathway in triple-negative breast cancer by benzylic organotrisulfides: Contribution of the released hydrogen sulfide towards potent anti-cancer activity" Free Radic. Biol. Med. 2022191, 82-96.

38.    Ravula, R.; Bhabak, K. P.; Mandal, T. K.* "User-friendly point of care test device for detection of arsenic in potable water: Prototype, design, and artifact" Asia-Pac. J. Chem. Eng2022, 17e2815. doi:10.1002/apj.2815
2023

42.    Sufian, A.; Badirujjaman, Md.;ξ Barman, P.;ξ Bhabak, K. P.* "Dual-Stimuli-Activatable Hybrid Prodrug for the Self-Immolative Delivery of an Anticancer Agent and Hydrogen Sulfide with Turn-on Fluorescence" Chem. Eur. J. 202329, e202302197
[ξ Contributed equally to the work]

The work has been selected as a Hot Paper
40.    Badirujjaman, Md.;ξ Pal, N.;ξ Bhabak, K. P.* "Small-molecule Organoselenocyanates: Recent Developments toward Synthesis, Anticancer and Antioxidant Activities" Curr. Opin. Chem. Biol.202375, 102337
[ξ: contributed equally]                               (Invited mini-review in the themed issue on Sulfur and Selenium)

41.    Mahato, S. K.; Barman, P.; Badirujjaman, Md.; Bhabak, K. P.* "Cysteine-responsive prodrug of the anti-cancer drug amonafide: fluorogenic adjuvant drug delivery with hydrogen sulfide (H2S)" Chem. Commun., 202359, 4802-4805.
44.  Kesarwani, R.; Pal, N.; Bhabak, K. P.* "Stimuli-responsive biotin-anchored prodrug for the targeted delivery of anti-cancer agent NBDHEX with turn-on NIR fluorescence" Chem. Commun. 202460, 3397-3400.

The work has been highlighted as Back-Cover of the Journal
43.    Sufian, A.; Parihar, N.;ξ Badirujjaman, M.;ξ Barman, P.;ξ Kesarwani, R.; Pemmaraju, D. B.*; Bhabak, K. P.* "Inflammatory-stimuli-responsive Turn-on NIR Fluorogenic Theranostic Prodrug: Adjuvant Delivery of Diclofenac and Hydrogen Sulfide Attenuates Acute Inflammatory Disorders" J. Mater. Chem. B 2024, 12, 4248-4261.
[ξ Contributed equally to the work]
45.  Misra, R.; Bhuyan, H.;ξ Dutta, A.;ξ Bhabak, K. P.* "Recent Developments On Activatable Turn-On Fluorogenic Donors of Hydrogen Sulfide (H2S)"      ChemMedChem, 202419, e202400251

[ξ Contributed equally to the work]       The work has been published as an "Invited Review" in the Journal


47.  Barman, P.; Misra, R.; Pal, N.; Sarkar, S.; Bhabak, K. P.* "Synthetic Benzylic Diselenides and Disulfides: Potential Anticancer Activities via Modulation of the ROS-dependent Akt/β-Catenin Signaling Pathway" ChemMedChem, 202419, e202400358

The work has been published as a part of the special collection "SABIC 2024"


46.  Misra, R.; Barman, P.; Bhabak, K. P.* "Esterase-Responsive Fluorogenic Prodrugs of Aldose Reductase Inhibitor Epalrestat: An Innovative Strategy toward Enhanced Anticancer Activity" ACS Appl. Bio. Mater., 20247, 6542-6553.

 Published as part of the special issue "Celebrating the 25th Anniversary of the Chemical Research Society of India"

The work has been highlighted as Front-Cover of the Journal


2024

50.  Pal, N.;ξ Banerjee, K.;ξ Sarkar, S.; Mandal, T. K.; Bhabak, K. P.* "Synthesis of Thiazolidinedione- and Triazole-Linked Organoselenocyanates and Evaluation of Anticancer Activities Against Breast Cancer with Mechanistic Investigations" Chem. Eur. J., 2024, (Accepted article)

ξThe authors contributed equally to the work

The work has been published as a part of the special collection "SABIC-2024"


48.  Banerjee, K.; Sufian, A.; Bhabak, K. P.* "Structurally Innovative Benzimidazole-fused Ionic Organoselenium Compounds: Prevalence of Se···N/Se Chalcogen Bonds with the Selenocyanate Receptor" Eur. J. Org. Chem., 2024, (Accepted article)



49.  Badirujjaman, M.; Thummer, R. P.*; Bhabak, K. P.* "Esterase-responsive Self-immolative Prodrugs for the Sustained Delivery of the Anticancer Drug 5-Fluorouracil with Turn-on Fluorescence" Chem. Asian J., 2024, (Accepted article)

The work has been published as a part of the special collection "Luminescent Materials: From Fundamentals to Applications (ICLMFA-2024)"