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| RESEARCH - PICTORIAL OVERVIEW |
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Bioorganic and Medicinal Chemistry/Chemical Biology/ Chemical Genomics/ Peptidomimetic Therapeutics Research in the interface of Chemistry and Biology is the only possible way to include real insights into the molecular mechanisms of complex biological and chemical systems. While this monumental research effort helped understanding the Physico-Chemical aspects of the natural bio-molecular recognition phenomena at molecular level, the aspiration to cure disease at the genetic level also acts as the major driving force behind the research between molecular biology and chemical synthesis. Synthetic molecules that bind sequence specifically to DNA and RNA are legitimate targets for molecular biology applications as gene therapeutic agents and in anti-sense technology. The multidisciplinary approach is one of the best devices to understand the bio-molecular recognition phenomena at molecular level and can be regarded as an icon for research at the interface of Chemistry and Biology. Thus, I am engaged in research activity at the interface of Chemistry and Biology, particularly, in the field of Bioorganic and Medicinal Chemistry/Chemical Biology/ Chemical Genomics/ Peptidomimetic Therapeutics as I envision that the efforts in these areas will provide deeper insights into the molecular mechanisms of complex biological systems and thus may help to cure diseases at the genetic level causing significant impact in health-care. My research group is also actively involved in Expanding the Genetic Alphabet (Chemical Genomics) which includes design of unnatural-fluorescent nucleoside pairs held by hydrophobic/charge transfer forces. On the other hand, we are simultaneously engaged in the design of solvatochromic fluorescent unnatural amino acids toward Expanding the Genetic Code (Chemical Biology) and searching for pharmacologically viable Peptidomimetic Therapeutics which can even target the recent pandemic COVID-19. In these research activities “Click reaction/chemistry” is associated as a key step which introduces triazole unit with high metabolic stability, associability with biological targets and ability to modulate electronic/photophysical properties. Our research group mainly focused on the Design, Synthesis, Spectroscopy, Biological and Theoretical study as well. A combination of both the fields will help in translating an expanded genetic alphabet to an expanded genetic code which provocatively, may even lead to the assembly of such a system within a living cell, potentially creating a semi-synthetic organism and life with increased diversity. We are also involved in the research “Toward the Goal for Personalized Medicine: Genotyping Single Nucleotide Polymorphism (SNPs) and Pharmacogenomics of Newly Designed Drugs” which includes the (a) Curing Diseases at Genetic Level, the Goal of “Personalized Medicine”, (b) Design of Fluorescent DNA probes for (i) SNPs typing and (ii) detection of DNA lesions via “Just Mix & Read Strategy”, (c) Detection of unlabeled DNA targets with New and Novel Microarray based on designed Fluorescent DNA probes, (d) Antisense Gene Therapy and (f) Peptidomimetics Drug Design. This research booming is now a day is the attractive target of all the biomedical researchers throughout the world to understand the genetic diseases and to develop the “Personalized Medicine”. In depth analysis and a closer look at my current research activities clearly state that all of my research works are directly in part or in full related to the consideration of health for the mankind. As a whole, the all Human Civilization will be benefited by my current research booming which will have a great impact on the overall Human Health. Our Group focuses mainly on: 1. Chemical Genomic/Expanding the Genetic Alphabets (Unnatural Nucleoside): (a) Expanding the Genetic Alphabets (b) Application in Drug Design: The New Nucleoside Base Analogues have Potential Biological Activity and may find Clinical use in Future for the Treatment of Viral Diseases such as COVID-19, AIDS, and Cancer. (c) Creating Semisynthetic Organism and Life with Enhanced Diversity. 2. Chemical Biology/Expanding the Genetic Codes (Unnatural Amino Acids): (a) Expanding the Genetic Codes (b) Application in Peptidomimetics Drug Design: For COVID-19 and Other SARS-CoV and Design of HIV-Protease-I Inhibitors (c) Concept of Umbrella Crowding and Drug Design via Enezyme Inhibition with the Conceptual β-Turn Mimetic Peptides. (d) Application-for Sensor Device: Peptide-based Organic Field Effect Transistor (POFET) Sensor for Sensing of Blood Protein for Biomedical Application and Chemical/Biological Warefare Agents. 3. Toward the Goal for Personalized Medicine: Genotyping Single Nucleotide Polymorphism (SNPs): (a) Curing Diseases at Genetic Level, the Goal of “Personalized Medicine” (b) Design of Fluorescent DNA probes for (i) SNPs typing and (ii) detection of other DNA lesions via “Just Mix & Read Strategy” (c) Application in DNA Chip: Novel Fluorescent DNA probes based DNA-Microarray for the detection of unlabeled DNA targets (d) Antisense Gene Therapy 4. Fluorescent β-Lactam Antibiotics (a) Development of Potent Fluorescent β-Lactam Antibiotics and Study of their Chemical and Biological Activity, (b) β-Lactam based Peptidomimetics and their Biological Activity; (c) Assay of Enzymatic Cleavage of β-Lactam Antibiotics by Fluorescence Spectroscopy. 5. Radical Generating Hybrid Organics as Anticancer Agents (Enediyne-Nucleoside/Peptide Conjugate) (a) Development of the Concept of Organic Radical-Nucleoside/Amino Acid Hybrid Molecules and Synthesis and Study of anti-Cancer Activity, (b) Monitoring the DNA hybridization guided DNA Cleavage by such Hybrid Molecules with Fluorescence Spectroscopy. 6. Biosensor/Chemical Sensor Development (a) Biochemical Fluorescent Sensor (b) Unnatural Amino acid for Fluorescence Discrimination of Alcohol (c) Fluorescent Monitoring of β-Lactamases (d) Label Free Detection of DNA with various Topology using Small Fluorescent Unnatural Nucleoside. (e) Peptide-based Organic Field Effect Transistor (POFET) Sensor for Sensing of Blood Protein for Biomedical Application and Chemical/Biological Warefare Agents. 7. Synthetic Methodology Development (a) Click-Sonogashira Coupling (b) One Pot Click and Sonogashira (c) Unnatural Aminoacid Atrop-Isomer as Catalyst for Asymmetric Synthesis. (d) Organic Photocatalysis 8. Nano-Biomaterials and Nano-Photocatalysis (a) Synthesis of Biologically Important Organic Materials via Heterogeneous Nano-Photo-Catalysis (b) Biomaterials for Burn Wound Healing Applications in Defence Sector. (c) Inhibiting the Virocidal Activity of SARS-CoV-2 using Nanomaterial (d) Photocatalytic Approach to Treat the Hospital/Community Generated Wastewater to Arrest the Spreading of COVID-19. |
