Laboratory of Peptide & Amyloid Research

Principal Investigator

Dr. Bhubaneswar Mandal (bmandal@iitg.ernet.in) :

He obtained his PhD from EPFL, Lausanne, Switzerland, under the supervision of Prof. Manfred Mutter on 2006. Then he joined the group of Prof. Herbert Waldmann and Dr. Hans-Dieter Arndt, Max-Planck Institute for Molecular Physiology, Dortmund, Germany, as a post doctoral fellow (Marie Curie Fellow) from 2007-2008. Presently he is an associate professor at the Department of Chemistry, IIT Guwahati. His area of research includes Alzheimer's disease, disruption of beta structure of amyloid forming peptide, mechanistic investigation of amyloid formation and also the development of new methodology for solution phase as well as solid phase peptide synthesis.

9.    Mr. Sandip Mondal

B.Sc. Chemistry(H) at Presidency College, Calcutta University.

M.Sc. Chemistry at School of Chemistry, University of Hyderabad.

Pursuing Ph.D. at Department of Chemistry Since July, 2016.

Area of research: Solution phase peptide synthesis and development of new coupling reagent.  

E-mail- sandy.cr7@iitg.ernet.in

8.  Ms. Rinku Dutta

B.Sc. Chemistry(H) at Berhampur Girls' College, Kalyani University.

M.Sc. Chemistry at Indian Institute of Technology Guwahati.

Pursuing Ph.D. at Department of Chemistry Since July, 2016.

Area of research: Design and development of drug against Alzheimer's disease.  

E-mail- drinku@iitg.ernet.in

7.    Mr. Gobinda Dolai

B.Sc. Chemistry(H) at Midnapore College, Vidyasagar University.

M.Sc. Chemistry at Indian Institute of Technology Guwahati.

Pursuing Ph.D. at Department of Chemistry Since July, 2016.

Area of research:    Site-selective peptide modification during solid phase peptide synthesis.

E-mail- gobindadolai@iitg.ernet.in

 B.Sc. Chemistry(H) at Arya Vidyapeeth College, Gauhati            University.

 M.Sc. Chemistry (Organic) at Gauhati University.

 Pursuing Ph.D. at Department of Chemistry Since July, 2015

 Area of research:    Development of breaker peptides against

 Alzheimer's Disease.

 E-mail- sujan.kalita@iitg.ernet.in

5.  Ms. Tapasi Kalita

B.Sc. Chemistry(H) at Ramjas College, Delhi University.

M.Sc. Chemistry (Organic) at Tezpur University.

Pursuing Ph.D. at Department of Chemistry Since Dec, 2014.

Area of research:  Solution phase peptide synthesis    and    other biological reactions. 

E-mail- tapasi@iitg.ernet.in

4.    Mr. Rajat Subhra Giri

B.Sc. Chemistry(H) at Midnapore College, Vidyasagar University.

M.Sc. Chemistry at Indian Institute of Technology Guwahati.

Pursuing Ph.D. at Department of Chemistry Since July, 2014.

Area of research:    Peptide engineering and Site specific modification of peptides.

E-mail- rajat.giri@iitg.ernet.in

3.    Ms. Jyoti Chandra

B.Sc. Chemistry(H) at Patna Science College, Patna University.

M.Sc. Chemistry at Indian Institute of Technology Kharagpur.

Pursuing Ph.D. at Department of Chemistry Since July, 2013.

Area of research:    Development of new strategies for peptide synthesis.

E-mail- j.chandra@iitg.ernet.in

2.    Mr. Srinivasa Rao Manne

B.Sc. Chemistry at Sri Y.N. College, Andhra University.

M.Sc. Chemistry (Organic) at V.S.K. College, Andhra University.

Pursuing Ph.D. at Department of Chemistry Since July, 2013.

Area of research:    Development of new coupling reagents for peptide and various organic synthesis.

E-mail- s.manne@iitg.ernet.in

1.    Mr. Tanmay Mondal

B.Sc. Chemistry(H) at Behala College, University of Calcutta.

M.Sc. Chemistry (Organic) at  Vidyasagar University.

Pursuing Ph.D. at Department of Chemistry Since July, 2013.

Area of research:    Peptido mimetics and Alzheimer's disease

E-mail- tanmay.mondal@iitg.ernet.in

Part-time Ph.D.  Students:

1.    Mr. Sourav Kalita

B.Sc. Chemistry(H) at B. Borooah College, Gauhati University.

M.Sc. Chemistry at Gauhati University.

Pursuing Ph.D. at Department of Chemistry Since July, 2014.   

Area of research:    Peptide mimetics and strategies for amyloid inhibition.

E-mail- sourav.kalita@iitg.ernet.in

5.   Dr. Dharm Dev (July, 2011 - Nov, 2016)

E-mail- d.dharm@iitg.ernet.in

Status: Successfully defended thesis on 25/11/2016 and pursuing postdoctoral studies in the Centre for Nano and Soft Matter Sciences, Bangalore under Prof. C.V. Yelamaggad.

Thesis Title:    Development of ortho-NosylOXY as a Novel Coupling Reagent for Peptide Synthesis and Related Organic Transformations.

4.    Dr. Ashim Paul (Dec, 2010 - June, 2016)

E-mail- p.ashim@iitg.ernet.in

Status: Successfully defended thesis on 06/06/2016 and secured a postdoctoral position at Tel Aviv University under Prof. Daniel Segal.

Thesis Title:    Development of New Strategies for Peptide Based Drug Design against Alzheimer's Disease .

3.    Dr. Kishore Thalluri (July, 2009 - October, 2014)

E-mail- thalluri@iitg.ernet.in

Current position: Successfully defended thesis on 17/10/2014 and working as post doctoral fellow under Prof. Richard DiMarchi, Standiford H. Cox Distinguished Professor of Chemistry, Linda & Jack Gill Chair in Biomolecular Sciences, Indiana University.

Thesis Title:    Development of Chemoselective and Stereoselective Strategies for Peptide Synthesis and Related Organic Transformations

2.    Dr. Nani Babu Palakurthy (Dec, 2008 - Jan, 2014)

E-mail- p.nani@iitg.ernet.in

Status: Successfully defended thesis on 31/01/2014 and pursuing postdoctoral studies in the Centre for Nano and Soft Matter Sciences, Bangalore.

Thesis Title:    Direct synthesis of aryl sulfonate esters and their applications in organic transformations

1.    Dr. Krishna Chaitanya Nadimpally (July, 2008 - Jan, 2014)

E-mail : n.chaitanya@iitg.ernet.in

Status: Successfully defended thesis on 23/01/2014 and has been selected for CSIR-Nehru postdoctoral fellowship at NCL Pune.

Thesis Title:   Concept of β-Breaker Dipeptides and its Application in Alzheimer’s Amyloid Disruption

 E-mail- nibeditachemkol@gmail.com

Area of research: Development of newer methodology for peptide synthesis.

1. Mr. Abhijit Saha (June, 2009 - April, 2012)

E-mail- s.abhijit@iitg.ernet.in

Area of research: Expanding the scope of oxo ester mediated NCL type chemoselective peptide ligation, sponsored by DAE (BRNS).

Presently he is pursuing doctoral studies in the famous group of  Prof. Hiroshi Sugiyama at Kyoto University, Japan.

Department: Department of Civil Engineering, IIT Guwahati

Thesis Title: Removal of mercury (ii) ions from waste water using cysteine polymer by adsorption process.

Joint Supervisor: Dr. Saswati Chakraborty, Assoc. Prof., Dept. of Civil Engineering, IIT Guwahati

Department of Chemistry, IIT Guwahati

Thesis Title: Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-Cyanoacetate (Boc-Oxyma) as coupling reagent for racemization free peptide synthesis.

Thesis Title: Ethyl 2-(tert-Butoxycarbonyloxyimino)-2-Cyanoacetate (Boc-Oxyma) as coupling reagent for racemization free peptide synthesis.

Thesis title: Synthesis and characterization of peptides that form amyloid like fibrils.

Thesis title: Synthesis of peptides by a non classical method.

Department of Chemistry, IIT Guwahati

Thesis Title: One pot synthesis of ureas from carboxylic acids via Curtius rearrangement using ethyl 2-cyano-2-(2- nitrobenzenesulfonyloxyimino) acetate (o- NosylOXY)

Thesis Title: Mild reduction of carboxylic acids to alcohols using ethyl 2-cyano-(2-nitrobenzenesulfonyloxyimino) acetate (o- NosylOXY) and sodium borohydride.

Thesis Title: Scale up of synthesis of ortho-nosyloxy and its catalytic effect in peptide synthesis.

Thesis Title: Synthesis and characterization of Various peptides relevant to Alzheimer's Disease.

6.        Mr. Kaushal Kishor Yadav (Jan, 2016 - April, 2016)

Thesis Title: Ferric Chloride  induced tert-butyl ester hydrolysis and its application in SPPS.

Thesis Title: Direct synthesis of sulphonate ester of oxyma under MW.

Thesis Title: Synthesis, characterization and bio-physical studies with three aggregation related peptides.

Thesis Title: Investigation on the catalytic activity of N-hydroxy benzotriazole on sulfonamide synthesis reaction.

Thesis Title: Preparation of phenolic Esters of N-benzoyl Glycine.

Thesis Title: Towards the development of a cheaper method for peptide based polymer synthesis.

Department of Chemistry, IIT Guwahati

9.       Mr. Soumya Kanti Sarkar   (June, 2016- July, 2016)

          Institute: ISM Dhanbad.

           Institute: ISM Dhanbad.

          Institute: Tezpur University.

           Institute: Gauhati University.

          Institute: Gauhati University.

          Institute: B. Borooah College, Gauhati University.

          Institute: Gauhati University.

          Institute: NIT Rourkela

           Project Title: Direct synthesis of sulfonamides from sulfonic acids

          Institute: NIT Rourkela

            Project Title: An expedient synthesis of O-benzyl hydroxamate using sulfonate esters

            Institute: Tezpur university, Assam

            Institute: Tezpur university, Assam

             Institute: NISER Bhubaneswar

            Project Title: Direct synthesis of sulfonamides from sulfonic acids.

           Institute: B. Borooah College, Guahati University.

           Institute: Tezpur University.

           Institute: Tezpur University.

           Institute: NIT Rourkela.

           Institute: B. Borooah College, Guahati University.

           Institute: B. Borooah College, Guahati University.

           Institute: B. Borooah College, Gauhati University.

           Institute: B. Borooah College, Gauhati University.

           Institute: B. Borooah College, Gauhati University.

           Institute: B. Borooah College, Gauhati University.