Biotalk
Biotalk is an extended lecture series spanning the entire academic year organized by Department of Biotechnology, IIT Guwahati. Speakers include, distinguished experts form academia and industry working in the inter-disciplinary areas of biotechnology along with faculty members and research students of the department.
Upcoming Talk
Title of the talk:" INSIGHTS INTO THE MECHANISMS THAT COUNTER GLYCATION-MEDIATED DAMAGE INPLANTS"
Speaker: P.V. ShivaprasadNational Centre for Biological Sciences,TIFR,GKVK Campus, Bellary Road, Bangalore
Date & Time: 2023-03-28, 5.00 PM
Venue : Seminar Hall, Dept of BSBE
Abstract of the Talk:
Plants being sessile are prone to genotoxin-induced macromolecule damage. Among the inevitable damaging agents are reactive carbonyls that induce glycation of DNA, RNA and proteins to result in the build-up of advanced glycated end products. However, it isunclear how plants repair glycated macromolecules. We show that ArabidopsisDJ-1D, a member of DJ-1/PARK7 family of moonlighting proteins, offers robust tolerance to endogenous and exogenous stresses through its ability to repair glycated DNA, RNA and proteins. DJ-1D also reduced the formation of reactive carbonyls through its efficient methylglyoxalase activity. Strikingly, full-length double domain containing DJ-1D suppressed the formation of advanced glycated end products in yeast and plants. DJ-1D alsoefficiently repaired glycated nucleic acids and nucleotides in vitroand mitochondrial DNA in vivounder stress, indicating the existence of a new DNA repair pathway in plants. We propose multi-stress responding plant DJ-1 members, often present in multiple copies among plants, likely contributed to the adaptation to a variety of endo-and exogenous stresses