Gupta Kapish
kapgupta@iitg.ac.in
Research Areas:
Toxicity Assay, Liver Mechanobiology, Cholestasis, Drug Testing, Biliary Atresia
Web page: https://sites.google.com/view/tmechlab
Journals
1. Gupta K, Xu JP, Diamond T, de Jong IEM, Glass A, Llewellyn J, et al. "Low-dose biliatresone treatment of pregnant mice causes subclinical biliary disease in their offspring: Evidence for a spectrum of neonatal injury.", PLoS One, DOI.10.1371/journal.pone.0301824 , Vol.19, 4, P.P - , (2024)
2. Gupta, K., Llewellyn, J., Roberts, E., Liu, C., Naji, A., Assoian, R. K., & Wells, R. G. " The biliary atresia susceptibility gene, EFEMP1, regulates extrahepatic bile duct elastic fiber formation and mechanics", JHEP Reports, DOI.10.1016/j.jhepr.2024.101215, Vol., , P.P - , (2024)
3. Gupta, K., Chen, D., Wells, R. G. "Microcystin-RR is a biliary toxin selective for neonatal extrahepatic cholangiocytes", JHEP Reports, DOI.10.1016/j.jhepr.2024.101218, Vol., , P.P - , (2024)
4. Gupta K "A Modular Analysis of Bile Canalicular Function and its Implications for Liver Cholestasis", American Journal of Physiology Gastrointestinal and Liver Physiology, DOI.10.1152/ajpgi.00165.2022 , Vol., , P.P - , (2023)
5. Du Y, DeJong IEM, Gupta K, Zinman OW, Zahav AH , Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck W, Wells RG. "Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease", Biofabrication, DOI.10.1088/1758-5090/ad0261, Vol.16, 1, P.P - , (2023)
6. de Jong IEM, Hunt ML, Chen D, Du Y, Llewellyn J, Gupta K, Li D, et al " A fetal wound healing program after intrauterine bile duct injury may contribute to biliary atresia", Journal of Hepatology , DOI.10.1016/j.jhep.2023.08.010, Vol.79, , P.P 1396-1407 , (2023)
7. Li Z, Chen Z, Gao Y, Xing Y, Zhou Y, Luo Y, Xu W, Chen Z, Gao X, Gupta K, et al " Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment. ", Biomaterials, DOI.10.1016/j.biomaterials.2022.121426, Vol., , P.P - , (2022)
8. Gupta K, Ng IC, Balachander GM, Nguyen BP, Tucker-Kellogg L, Low BC, Yu H. "Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel", Biomaterials, DOI.10.1016/j.biomaterials.2020.120283, Vol., , P.P - , (2020)
9. Tasnim F, Singh NH, Tan EKF, Xing J, Li H, Hissette S, Manesh S, Fulwood J, Gupta K, Ng CW, Xu S, Hill J, Yu H. "Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing", Scientific Reports, DOI.10.1038/s41598-020-61699-4, Vol.10, , P.P - , (2020)
10. O’Keeffe A, Hale C, Cotton JA, Yardley V, Gupta K, Ananthanarayanan A, Murdan S, Croft SL "Novel 2D and 3D Assays to Determine the Activity of Anti-Leishmanial Drugs", Microorganisms, DOI.10.3390/microorganisms8060831, Vol.8, 6, P.P - , (2020)
11. Sun M, Wong JY, Nugraha B, Ananthanarayanan A, Liu Z, Lee F, Gupta K, Fong ELS, Huang X, Yu H. " Cleavable cellulosic sponge for functional hepatic cell culture and retrieval", Biomaterials, DOI.10.1016/j.biomaterials.2019.01.046, Vol., , P.P - , (2019)
12. Chua ACY, Ananthanarayanan A, Ong JJY, Wong JY, Yip A, Singh NH, Qu Y, Dembele L, McMillian M, Ubalee R, Davidson S, Tungtaeng A, Imerbsin R, Gupta K, Andolina C, Lee F, S-W Tan K, Nosten F, Russell B, Lange A, Diagana TT, Rénia L, Yeung BKS, Yu H, Bifani P. " Hepatic spheroids used as an in vitro model to study malaria relapse.", Biomaterials, DOI.10.1016/j.biomaterials.2019.05.032, Vol., , P.P - , (2019)
13. Dasgupta S, Gupta K, Zhang Y, Viasnoff V, Prost J. " Physics of lumen growth", Proceedings of the National Academy of Sciences of The United States of America, DOI.10.1073/pnas.1722154115, Vol., , P.P - , (2018)
14. Luo X, Gupta K, Ananthanarayanan A, Wang Z, Xia L, Li A, Sakban RB, Liu S, Yu H "Directed Differentiation of Adult Liver Derived Mesenchymal Like Stem Cells into Functional Hepatocytes", Scientific Reports, DOI.10.1038/s41598-018-20304-5, Vol., , P.P - , (2018)
15. Gupta K, Li Q, Fan JJ, Fong ELS, Song Z, Mo S, Tang H, Ng IC, Ng CW, Pawijit P, Zhuo S, Dong CY, Low BC, Wee A, Dan YY, Kanchanawong P, So P, Viasnoff V, Yu H. " Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis.", Journal of Hepatology, DOI.10.1016/j.jhep.2017.01.026, Vol.66, 6, P.P 1231-1240 , (2017)
16. Song Z*, Gupta K*, Ng IC, Xing J, Yang YA, Yu H. (*Co-first author) "Mechanosensing in liver regeneration", Seminars In Cell & Developmental Biology, DOI.DOI: 10.1016/j.semcdb.2017.07.041, Vol., , P.P - , (2017)
17. Gupta K, Jana AK, Kumar S, Jana MM. " Solid state fermentation with recovery of amyloglucosidase from extract by direct immobilization in cross linked enzyme aggregate for starch Hydrolysis. ", Biocatalysis And Agricultural Biotechnology, DOI.10.1016/j.bcab.2015.07.007, Vol.4, 4, P.P 486-492 , (2015)
18. Gupta K, Jana AK, Kumar S, Maiti M "Immobilization of ?-amylase and amyloglucosidase onto ion-exchange resin beads and hydrolysis of natural starch at high concentration", Bioprocess And Biosystems Engineering, DOI.10.1007/s00449-013-0946-y, Vol.36, 11, P.P 1715-1724 , (2013)
19. Gupta K, Jana AK, Kumar S, Maiti M " Immobilization of amyloglucosidase from SSF of Aspergillus niger by crosslinked enzyme aggregate onto magnetic nanoparticles using minimum amount of carrier and characterizations", Journal of Molecular Catalysis B: Enzymatic., DOI.10.1016/j.molcatb.2013.09.015 , Vol.98, , P.P 30-36 , (2013)
Conference Publication
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Book
No Data Available!
Book Chapter
1. Gupta K, Song Z, Tang H, Fong ELS, Ng IC, Yu H. " Comprehensive Biomaterials II", Oxford: Elsevier. Vol., 9780081006924, P.P 491-513- , (2017)