Kumar Manish
mkumar1@iitg.ac.in
Research Areas:
Molecular interaction of host-pathogen-vector of infectious diseases
Journals
1. Kumari S and Kumar M "The ClpA chaperone and the two adaptor proteins modulate the fate of the model substrate tagged with a SsrA-degron of Leptospira", Biochemical Journal, DOI.https://doi.org/10.1042/BCJ20253143, Vol., bcj-2025-3143, P.P 1-23 , (2025)
2. Kumari S, Ali A, Kumar M "Nucleotide-induced ClpC oligomerization and its non-preferential association with ClpP isoforms of pathogenic Leptospira", International Journal of Biological Macromolecules, DOI.10.1016/j.ijbiomac.2024.131371, Vol., , P.P - , (2024)
3. Hota S and Kumar M "ErpY-like protein interaction with host thrombin and fibrinogen intervenes the plasma coagulation through extrinsic and intrinsic pathways", ACS Infectious Diseases, DOI.DOI: 10.1021/acsinfecdis.4c00266, Vol., , P.P - , (2024)
4. Hota S and Kumar M " Unveiling the impact of Leptospira TolC efflux protein on host tissue adherence, complement evasion, and diagnostic potential", Infection and Immunity, DOI.doi/10.1128/iai.00419-24, Vol.92, 11, P.P 1-26 , (2024)
5. Hussain MS, Anand V, Kumar M " Functional PAM sequence for DNA interference by CRISPR-Cas I-B system of Leptospira interrogans and the role of LinCas11b encoded within lincas8b", International Journal of Biological Macromolecules, DOI.https://doi.org/10.1016/j.ijbiomac.2023.124086, Vol.237, 124086, P.P 1-14 , (2023)
6. Anand V; Harshini SP; Prakash A; Hussain MS; Kumar M " Differential processing of CRISPR RNA by LinCas5c and LinCas6 of Leptospira", BBA - General Subjects, DOI.https://doi.org/10.1016/j.bbagen.2023.130469, Vol.1867, 12, P.P 1-12 , (2023)
7. Kumari S, Dhara A, Kumar M "Leptospira ClpP mutant variants in association with the ClpX, acyldepsipeptide, and the trigger factor displays unprecedented gain-of-function", International Journal of Biological Macromolecules, DOI.https://doi.org/10.1016/j.ijbiomac.2023.127753, Vol., , P.P - , (2023)
8. Anand V, Harshini SP, Gogoi P, Kanaujia SP and Kumar M " Structural and functional characterization of Cas2 of CRISPR-Cas subtype I-C lacking the CRISPR component", Frontiers in Molecular Biosciences, DOI.10.3389/fmolb.2022.988569 , Vol.988569, 9, P.P -15 , (2022)
9. Hussain MS, Kumar M " Assembly of Cas7 subunits of Leptospira on the mature crRNA of CRISPR-Cas I-B is modulated by divalent ions", Gene, DOI.10.1016/j.gene.2022.146244, Vol., , P.P - , (2022)
10. Hota S, Hussain MS, Kumar M " ErpY-like lipoprotein of Leptospira outsmart host complement regulation by acquiring complement regulators, activating alternative pathways, and intervening in the membrane attack complex", ACS Infectious Diseases, DOI.10.1021/acsinfecdis.1c00602 , Vol.8, 5, P.P 982-997 , (2022)
11. Prakash A, Kumar M "Transcriptional analysis of CRISPR I-B arrays of Leptospira interrogans serovar Lai and its processing by Cas6", Front. Microbiol., DOI. 10.3389/fmicb.2022.960559 , Vol.13, 960559, P.P 1-13 , (2022)
12. Dhara A, Hussain M S, Kanaujia S P, Kumar M "Acyldepsipeptide activated ClpP1P2 macromolecule of Leptospira, an ideal Achilles’ heel to hamper the cell survival and deregulate ClpP proteolytic activity", Research in Microbiology, DOI.10.1016/j.resmic.2021.103797, Vol., , P.P - , (2021)
13. Harshini S P, Ghosh K K, Kumari R R, Kumar P, Kumar M "Evaluation of sporozoite and macroschizont antigen (Spm2) of Theileria annulata for its diagnostic potential", Ticks and Tick-borne Diseases, DOI.https://doi.org/10.1016/j.ttbdis.2021.101691, Vol.12, 4, P.P - , (2021)
14. Prakash A, Kumar M "Characterizing the transcripts of Leptospira CRISPR I-B array and its processing with endoribonuclease LinCas6", International Journal of Biological Macromolecules, DOI.10.1016/j.ijbiomac.2021.04.066, Vol.182, , P.P 785-795 , (2021)
15. Dixit B, Anand V, Hussain M S, Kumar M "The CRISPR-associated Cas4 protein from Leptospira interrogans demonstrate versatile nuclease activity", Current Research in Microbial Sciences, DOI.10.1016/j.crmicr.2021.100040, Vol.2, 100040, P.P - , (2021)
16. Hota S, Hussain M S, Kumar M " ErpY-like lipoprotein of Leptospira outsmart host complement regulation by acquiring complement regulators, activating alternate pathway, and intervening membrane attack complex", bioRxiv, DOI.10.1101/2021.05.27.446086 , Vol., , P.P - , (2021)
17. Kumar P, Kumar P, Roy R K, Kumari R R, Kumar A, Sarma K, Sharma P, Kumar M "Mixed Infection of Tick-borne Haemo-parasites in Water Buffalo and Associated Pathological Responses and Treatment", Indian Journal Of Animal Research, DOI.10.18805/IJAR.B-4450 , Vol., , P.P 1-9 , (2021)
18. Dixit B, Prakash A, Kumar P, Gogoi P, Kumar M " The core Cas1 protein of CRISPR-Cas I-B in Leptospira shows metal-tunable nuclease activity", Current Research in Microbial Sciences, DOI.10.1016/j.crmicr.2021.100059, Vol., 2, P.P - , (2021)
19. Kumar P, Kumari RR, Devi S, Tripathi MK, Singh J, Kumar R, Kumar M "Emergence and transboundary spread of lumpy skin disease in South Asia", Indian Journal Of Animal Sciences, DOI., Vol.7, 91, P.P 507-517 , (2021)
20. Kumar P, Kumari R R, Kumar A, Raman R K, Chandran P C, Kumar M " Status of Subclinical Mastitis in Crossbred Cattle of Peri-urban Unorganized Herd of Middle Indo-gangetic Plains.", Indian Journal of Animal Research, DOI.10.18805/IJAR.B-4241, Vol., , P.P - , (2020)
21. Choudhury M, Dhara A and Kumar M " Trigger factor in association with the ClpP1P2 heterocomplex of Leptospira promotes protease/peptidase activity", ACS Omega, DOI.10.1021/acsomega.0c05057, Vol., , P.P - , (2020)
22. Saha G, Chiranjivi AK, Khamar BM, Prerna K, Kumar M and Dubey VK " BLIMP-1 Mediated Downregulation of TAK1 and p53 Molecules Is Crucial in the Pathogenesis of Kala-Azar. ", Front. Cell. Infect. Microbiol., DOI.10.3389/fcimb.2020.594431, Vol.10, 594431, P.P - , (2020)
23. Ghosh K K *, Prakash A *, Dhara A , Hussain M S , Shrivastav P , Kumar P , Balamurugan V, Kumar M "Role of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its Diagnostic Potential", Infection and Immunity , DOI.10.1128/IAI.00536-19, Vol.87, 12, P.P e00536-19-e00536-19 , (2019)
24. Saha G, Khamar B, Kumari P, Kumar M, Dubey V. "BLIMP-1 plays important role in the regulation of macrophage pyroptosis for the growth and multiplication of Leishmania donovani", ACS Infectious Diseases , DOI.10.1021/acsinfecdis.9b00186, Vol.5, 12, P.P 2087-2095 , (2019)
25. Kumari R K, Kumar R, Kumar P, Kumar M. " Emergence and variations in disease ecology of tick-borne bovine theileriosis in East India", International Journal of Livestock Research , DOI.http://dx.doi.org/10.5455/ijlr.20190920061236, Vol.9, 11, P.P 12-25 , (2019)
26. Dhara A, Hussain M S, Datta D, Kumar M " Insights to the assembly of functionally active leptospiral ClpP1P2 protease complex along with its ATPase chaperone ClpX", ACS omega, DOI., Vol.4, , P.P 12880-12895 , (2019)
27. Ghosh K K, Prakash A, Shrivastav P, Balamurugan V, Kumar M " Evaluation of a novel outer membrane surface-exposed protein, LIC13341 of Leptospira, as an adhesin and serodiagnostic candidate marker for leptospirosis", Microbiology, DOI., Vol.164, 8, P.P 1023-1037 , (2018)
28. Ghosh K K, Prakash A, Balamurugan V, Kumar M. "Catecholamine modulated novel surface exposed adhesin LIC20035 of Leptospira binds host extracellular matrix components and is recognized by host during infection. ", Applied and environmental microbiology, DOI., Vol.84, 6, P.P e02360-e02317 , (2018)
29. Kumar P, Barari S K, Tripathi M K, Kumari R R, Kumar M " Foot and Mouth Disease: An Economically Devastating Disease of the livestock.", Journal of Veterinary Sciences, DOI., Vol.4, 1, P.P - , (2018)
30. Kumar P, Dey A, Kumar A, Ray PK, Chandran PC, Kumari RK, Kumar M " The effects of PPR on the reproductive health of Black Bengal goats and the possible role played by oxidative stress.", Tropical Animal Health and Production, DOI., Vol., doi: 10.1007/s11250-018-1578-7, P.P - , (2018)
31. Singh P, Verma D, Backstedt BT, Kaur S, Kumar M, Smith AA, Sharma K, Yang X, Azevedo JF, Gomes-Solecki M, Buyuktanir O, Pal U. "Borrelia burgdorferi BBI39 paralogs are targets of protective immunity inducing microbicidal responses and reducing pathogen persistence either in hosts or in the vector.", The Journal of Infectious Diseases, DOI., Vol.Jan 31. doi:10.1093/infdis/jix036., , P.P - , (2017)
32. Dixit B, Ghosh K K, Fernandes G, Kumar P, Gogoi P, Kumar M "Dual nuclease activity of a Cas2 protein in CRISPR-Cas subtype I-B of Leptospira interrogans", FEBS Letters, DOI., Vol.590, 7, P.P 1002-1016 , (2016)
33. Kumar P, Pandian S J, Kumari RR, Kumar M. "Package and practices for Livestock Farmers: Under supervision of a Veterinarian. ", Poulvet;Online journal http://poulvet.com/dairy/articles/livestock_farmers.php , DOI., Vol., , P.P - , (2016)
34. Kumar P, Pandian SJ, Sinha BS, Kumari RK, Kumar M. "Calf Diarrhoea: Devastating disease of bovine during first three months after birth.", http://www.krishisewa.com/articles/livestock/705-calf-diarrhoea.html, DOI., Vol., , P.P - , (2016)
35. Kumar P, Roy RK, Kumar M, Kumari RK, Kumar A. "PPR control in Goat: A guide for animal health service providers. ", http://www.vethelplineindia.co.in/ppr-control-in-goat-a-guide-for-animal-health-service-providers/, DOI., Vol., , P.P - , (2015)
36. Kumar P, Kumari R R, Kumar M, Kumar S, Chakrabarti A. " Current practices and research updated on Diabetes mellitus in Canine", Veterinary World, DOI., Vol.7, 11, P.P 952-959 , (2014)
37. Ouyang Z, Narasimhan S, Neelakanta G, Kumar M, Pal U, Fikrig E, Norgard M V. " Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi", BMC Microbiology , DOI., Vol.44, 12, P.P doi:10.118- , (2012)
38. Kumar M, Kaur S, Kariu T, Yang X, Bossis I, Anderson JF, Pal U. ""Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccines”", Vaccine, DOI., Vol.29, 48, P.P 9012-9019 , (2011)
39. Xiao S*, Kumar M*, Yang X, Akkoyunlu M,Collins P L, Samal S K, Pal U. " An efficient avian host-restricted viral vector for antigen-specific host immunization against Lyme disease pathogens", Vaccine, DOI., Vol.29, 32, P.P 5294-5303 , (2011)
40. Kumar M, Bhilegaonkar KN, Agarwal RK. "“Prevalence and characterization of rotavirus from faecal samples of children and animals”", Indian Journal of Animal Sciences, DOI., Vol.81, 10, P.P 993-999 , (2011)
41. Kumari R R, Kumar M, Kumar P. " An Integrated Approach to Control Toxocara vitulorum: A Major Cause of Buffalo Calf Mortality. ", Livestock International, DOI., Vol.15, 2, P.P 8-9 , (2011)
42. Kumar M, Yang X, Coleman A S, Pal U. "BBA52 facilitates Borrelia burgdorferi transmission from feeding ticks to murine hosts", The Journal of Infectious Diseases, DOI., Vol.201, 7, P.P 1084-1095 , (2010)
43. Zhang X, Yang X, Kumar M, Pal U. "BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle", The Journal of Infectious Diseases, DOI., Vol.200, 8, P.P 1318-1330 , (2009)
44. Promnares K, Kumar M, Shroder D Y, Zhang X, Anderson J F, Pal U " Borrelia burgdorferi small lipoprotein Lp6.6 is a member of multiple protein complexes in the outer membrane and facilitates pathogen transmission from ticks to mice", Mol Microbiol, DOI., Vol.74, 1, P.P 112-125 , (2009)
45. Ouyang Z, Kumar M, Kariu T, Haq S, Goldberg M, Pal U, Norgard M V. "BosR (BB0647) governs virulence expression in Borrelia burgdorferi", Mol Microbiol, DOI., Vol.74, 6, P.P 1331-1343 , (2009)
46. Kumari RR, Kumar P, Kumar M " Nutritional Deficiency Diseases of Newborn Farm Animals and There Management.", Intas Polivet, DOI., Vol.10, 2, P.P - , (2009)
47. Pal U, Dai J, Li X, Neelakanta G, Luo P, Kumar M, Wang P, Yang X, Anderson J F, Fikrig E. " A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks", The Journal of Infectious Diseases, DOI., Vol.197, 1, P.P 148-155 , (2008)
48. Coleman A S, Yang X, Kumar M, Zhang X, Promnares K, Shroder D, Kenedy M R, Anderson J F, Akins D R, Pal U "Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity", PLoS ONE, DOI., Vol.3, (8):3010e, P.P - , (2008)
49. Kumar P, Challa J, Dimri U & Kumar M. " Role of Micro-nutrients in dermatological disorders of dog.", Intas Polivet., DOI., Vol.8, 2, P.P 465-471 , (2007)
50. Kumar M, Bhilagaonkar KN, Kumar P. "Epidemiology of Japanese Encephalitis in the Indian Scenario", Intas Polivet, DOI., Vol.7, (II), P.P 312-319 , (2006)
51. Kumar P, Kumar M, Mudgal V, Mishra S K. " Awareness for nutritional management in Pet animals", Pet India, DOI., Vol.11, 6, P.P 48-50 , (2005)
52. Kushwaha R B, Shankar U, Kumar P, Kumar M. " Pyometra in canines: an appraisal", Poulvet .Online in www.poulvet.com/articles/ pyometra_article. , DOI., Vol., , P.P - , (2005)
53. Kumar P, Kumar M, Prasanna S B, Singh S K. "First Aid assistance for companion animal during emergency", Pet India, DOI., Vol.10, 12, P.P 15-17 , (2004)
Conference Publication
1. Md. Saddam Hussain, Manish Kumar "The burgeoning CRISPR-Cas applications", Biotechnological Approaches in Animal Research and Disease Diagnosis. Vol., , P.P - , ()
2. Kumar, Manish; Bhilegaonkar, K.N; Kumar, Pankaj & Sharma, M.C. "Public health awareness among livestock farmers for sustaining economy. ", National Seminar on Micro Enterprise Promotion in rural India, Experience, Prospects & Strategies, IVRI, Izatnagar, India.. Vol., , P.P - , (2005)
3. Kumar, Manish; Bhilegaonkar, K.N; Agarwal, R.K. " Prevalence and rapid detection of Salmonella and E.coli in diarrhoeal cases of children and calves and piglets.", International symposium on “Food safety, Quality Assurance & Global Trade: Concerns and Strageies” on the occasion of Annual conference of Indian Asssociation of Veterinary Public health Specialists, GBPUA&T, Pantnagar, Uttarakhand, India. . Vol., , P.P - , (2008)
4. Kumar, Manish; Bhilegaonkar, K.N; Agarwal, R.K. & Kumar, Pankaj. " RT-PCR for detection of rotavirus from faecal samples of children and animals. ", Annual conference of Indian Association of veterinary Microbiologists, Immunologists & Specialists in Infectious Diseases and national Symposium on Newer concepts and strategies for Disease Diagnostics & Immunoprophylactics for enhancing Livestock health & production., IVRI, Izatnagar, India.. Vol., , P.P - , (2008)
5. Kumar, Pankaj, Sharma, M.C., Kumar Manish and Swarup, D. " Oxidative stress and genotoxicity in relation to micro-mineral deficiency in cattle of Bihar districts.", Pp 183, Proceedings of the International Summit on “Advancing veterinary Medical care: Challenges and Strategies” and 27th ISVM convention Satellite Seminar on Veterinary Internal Medicine” 19-21 Feb, 2009.. Vol., , P.P - , (2009)
6. Soloski M J, Kumar M, Wu G, Ji H, Kortte K, Crowder L, Aucott J. " Immune Profiling of Early Lyme Disease.", ID Week, 17-21 oct,2012 San Diego, California, USA.. Vol., , P.P - , (2012)
7. Kung F, Kumar M, Promnares K, Yang X, Pal U " Role of bbd18 in Borrelia burgdorferi Biology and Infectivity. ", Graduate Research Interaction Day (GRID). College Park, Maryland, USA.. Vol., , P.P - , (2014)
8. Dixit B, Kumar M " A novel Cas2 Protein of CRISPR/Cas system in Leptospira interrogans displaying dual nuclease activity.", 9th Scientific meeting of International Leptospirosis society,7-10 Oct, 2015 Semarang, Indonesia.. Vol., , P.P - , (2015)
9. Ghosh K K, Kumar M "Characterization of hypothesized outer membrane protein of Leptospira interrogans Copenhageni.", 8th Indo Global summit and Expo on Vaccines,Therapeutics & healthcare, November 02-04, 2015 HICC, Hyderabad, India. (Best Paper award). Vol., , P.P - , (2015)
10. Dixit B, Kumar M "Characterization of one of core Cas protein of CRISPR-Cas Subtype I-B in Leptospira interrogans Copenhageni strain Fiocruz L1-130.", Innovative Research in Biotechnology, Biomedical Sciences, Bioinformatics and Stem Cell application in JNU, New Delhi. (Best poster award). Vol., , P.P - , (2016)
11. Dixit B, Kumar M "Characterization of Cas1 protein of CRISPR Cas subtype I-B Leptospira interrogans Copenhageni strain Fiocruz L1-130.", Global Symposium on “Animal Health: Newer Technologies and their Applications” in Veterinary College Khanapara.. Vol., , P.P - , (2016)
12. Prakash A, Kumar M. " Cloning and expression of novel Lon Protease of Leptospira interrogans Copenhageni Strain Fiocruz L1-130.", Global Symposium on “Animal Health: Newer Technologies and their Applications” in Veterinary College Khanapara.. Vol., , P.P - , (2016)
13. Ghosh K K, Kumar M. " In vitro expression analysis of selected outer membrane proteins of Leptospira interrogans Copenhageni strain Fiocruz L1-130 for diagnostics and vaccination.", Global Symposium on “Animal Health: Newer Technologies and their Applications” in Veterinary College Khanapara.. Vol., , P.P - , (2016)
14. Prakash A, Kumar M " Characterization of a novel Cas5 protein of CRISPR-Cas type I-B in pathogenic Leptospira interrogans.", 57th Annual Conference of Association of Microbiologists of India and International symposium on “Microbes and Biosphere” in Gauhati University, Assam. . Vol., , P.P - , (2016)
15. Ghosh K K, Kumar M. "Modulation of gene expression of Leptospira interrogans exposed to catecholamines and its role in host immune evasion.", 57th Annual Conference of Association of Microbiologists of India and International symposium on “Microbes and Biosphere” in Gauhati University, Assam.. Vol., , P.P - , (2016)
16. Basumatary B, Kumar M. " Investigation of biochemical characteristics of a core Cas protein in CRISPR-Cas subtype-IC in Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130. ", 57th Annual Conference of Association of Microbiologists of India and International symposium on “Microbes and Biosphere” in Gauhati University, Assam. . Vol., , P.P - , (2016)
17. Dhara A, Kumar M. "Cloning, expression and purification of Caseinolytic proteases of pathogenic Leptospira interrogans Copenhageni strain Fiocruz L1-130. ", 57th Annual Conference of Association of Microbiologists of India and International symposium on “Microbes and Biosphere” in Gauhati University, Assam.. Vol., , P.P - , (2016)
18. Kumar M "Immunogenic Lipoprotein LP46 of Leptospira interrogans interacts with host extracellular matrix components.Opportunities and Challenges of Translational Research in the Frontier Areas of Animal Biotechnology", OUAT National seminar, Bhubaneswar. Vol., , P.P - , (2017)
19. Kumar M " Analysis of Differential Expression of Outer Membrane Proteins of pathogenic Leptospira in response to catecholamine: a host stress factor.", ICAR-NIVEDI meeting, Bengaluru. Vol., , P.P - , (2017)
20. Ghosh K K, Kumar M. "Catecholamines as chemical messengers for host-Leptospira interaction.", Research conclave'18. Vol., , P.P 168-169 , (2018)
21. Aman Prakash, Karukriti Kaushik Ghosh, Manish Kumar " Characterization of Leptospira putative lipoprotein LIC11966 and its serological diagnostic application in diverse hosts including humans", National Conference VIBCON-2018 in Nagaland on “Innovative Biotechnological Approaches for Improving Animal Health and Productivity”. Vol., , P.P 56-56 , (2018)
22. Aman Prakash, Manish Kumar " Identification and characterization of essential elements involved in CRISPR expression and maturation in pathogenic Leptospira interrogans", International Conference on Recent Research in Biomedical Engineering, Cancer Biology, Stem Cells, Bioinformatics and Applied Biotechnology (BECBAB-2018) in JNU, New Delhi. Vol., , P.P - , (2018)
23. Harshini SP, Pankaj Kumar, Manish Kumar " Cloning and expression of sporozoite and macroschizont (spm2) protein from genomic DNA of Theileria annulata isolated from the cattle blood sample.", National Conference VIBCON-2018 in Nagaland on “Innovative Biotechnological Approaches for Improving Animal Health and Productivity”. Vol., , P.P 59-59 , (2018)
24. Anusua Dhara, Manish Kumar "Two isoforms of Caseinolytic proteases (ClpPs) of Leptospira interrogans are essential for functional activity", World Congress on Infectious Diseases & Antibiotics – 2018, Bangalore.. Vol., , P.P - , (2018)
25. Dr. Manish Kumar "Leptospira putative lipoprotein LIC11966 is a fibrinogen binding protein of diagnostic importance.", VIBCON 2018 . Vol., , P.P 14-16 , (2018)
26. Saha G, Khamar B.M, Kumar M, Dubey V.K " Unraveling the role of BLIMP-1 induction during Leishmania donovani infection as a novel escape mechanism", 17th International conference of Immunology, Oct 19-23, 2019 Beijing China. Vol.49, S3, P.P 1174-1175 , (2019)
27. Aman Prakash and Manish Kumar "Potential application of supramolecule ErpY-Like lipoprotein of Leptospira as anticoagulant, complement regulation, and leptospirosis diagnostic kit development", Global Bio-India 2019. Vol., , P.P - , (2019)
28. Md. Saddam Hussain, Manish Kumar "Biochemical characterization of CRISPR-Cas Cascade complex subunit protein-Cas7 in Leptospira interrogans Copenhageni Strain Fiocruz L1- 130", Research conclave’19 at IITG. Vol., , P.P - , (2019)
29. Md. Saddam Hussain, Manish Kumar "Leptospira Cas8b protein: a genetic fusion of large and small subunit of CRISPR-Cas type I-B Cascade complex", Emerging areas in Biosciences and Biomedical Technologies-2 (eBBT-2). Vol., , P.P 46-46 , (2020)
30. Madhurima Choudhury, Manish Kumar " The novel role of trigger factor in stimulating caseinolytic serine protease activity of Leptospira", Emerging Areas in Biosciences and Biomedical Technologies-2. Vol., , P.P 47-47 , (2020)
31. Vineet Anand and Manish Kumar " Biochemical characterization of a core Cas protein of CRISPR-Cas subtype-IC in Leptospira interrogans serovar Copenhageni strain Fiocruz L1-130", Challenges and Threats of Microbes to Animals and Humans. Vol., , P.P - , (2020)
32. Md. Saddam Hussain, Manish Kumar "The burgeoning CRISPR-Cas applications", Biotechnological Approaches in Animal Research and Disease Diagnosis. Feb 6, 2021 GADVASU, Ludhiana. Vol., , P.P - , (2021)
33. Saswat Hota, Manish Kumar " The surface-exposed, ErpY-like protein of Leptospira assists in complement evasion by acquiring factor H and I ", International Conference on Biotechnology for Resource Efficiency, Energy, Environment, Chemicals and Health. Dec 4, 2021, CSIR Dehradun. Vol., , P.P - , (2021)
34. Surbhi Kumari, Manish Kumar "Functional insight into association of ATPase chaperones with the caseinolytic protease of pathogenic Leptospira", Serine Proteases in Pericellular Proteolysis and Signaling. Oct 29, ASBMB, Rockville, Maryland. Vol., , P.P - , (2021)
35. Manish Kumar, Md Saddam Hussain, Aman Prakash, Vineet Anand " LinCas11, a small subunit of interference complex in Leptospira interrogans CRISPR-Cas I-B locus, is a pre-requisite for the targeted annihilation of DNA in a surrogate host", 12th International Leptospirosis Society Conference 2022, Nov 13-16, Bangkok, Thailand . Vol., , P.P - , (2022)
36. Saswat Hota & Manish Kumar "ErpY-like protein: A surface-exposed leptospiral protein assists in complement evasion and plasma coagulation inhibition", International Symposium on “Zoonotic and Transboundary Diseases: Breaking the Chain through Multidisciplinary Approach, 1-2 December 2022, ICAR Research complex, Umiam, Meghalaya. Vol., , P.P 158- , (2022)
37. Md. Saddam Hussain and Manish Kumar " Molecular and functional insight of CRISPR-Cas type I-B interference complex in pathogenic Leptospira interrogans", International Symposium on “Zoonotic and Transboundary Diseases: Breaking the Chain through Multidisciplinary Approach and IAVPHS, 1-2 December 2022, ICAR Research complex, Umiam, Meghalaya . Vol., , P.P 168- , (2022)
38. Surbhi Kumari and Manish Kumar "Functional insight into leptospiral caseinolytic protease and their association with ATPase chaperones", International Symposium on “Zoonotic and Transboundary Diseases: Breaking the Chain through Multidisciplinary Approach and IAVPHS, 1-2 December 2022, ICAR Research complex, Umiam, Meghalaya. Vol., , P.P 169- , (2022)
39. Manish Kumar " Implementation of CRISPR-Cas system of spirochetes as an endogenous genome editing tool", National Bioengineering conference, NIT Rourkela, 6-7 Jan 2022. Vol., , P.P - , (2022)
40. Surbhi Kumari and Manish Kumar "Site-directed ClpP mutation of Leptospira demonstrate unprecedented gain-of-function", VII Annual Convention of SVBBI and International Symposium on “Multiomics to One Health: Challenges and Way Forward in Biomedical Research”, 14-15 December 2023, Division of Biochemistry, IVRI, Izatnagar, Bareilly-243122 (U.P.). Vol., , P.P - , (2023)
41. Saswat Hota and Manish Kumar " Fibrinogen binding ErpY-like protein of Leptospira interferes in the coagulation of host blood plasma by inhibiting fibrin polymerization", VII Annual Convention of SVBBI and International Symposium on “Multiomics to One Health: Challenges and Way Forward in Biomedical Research”, 14-15 December 2023, Division of Biochemistry, IVRI, Izatnagar, Bareilly-243122 (U.P.) (Second prize in Oral presentation). Vol., , P.P - , (2023)
42. Manish Kumar "Deciphering the Leptospira-host interaction to develop various diagnostics and intervention strategies", VII Annual Convention of SVBBI and International Symposium on “Multiomics to One Health: Challenges and Way Forward in Biomedical Research", 14-15 December 2023, Division of Biochemistry, IVRI, Izatnagar, Bareilly-243122 (U.P.).. Vol., , P.P - , (2023)
43. Kumar M, Kumari S "Insight into the association of ClpC chaperone with the caseinoytic protese of pathogenic Leptospira", International Leptospirosis Society, 2024, Brussels, Belgium, 2-4 Sept 2024. Vol., , P.P - , (2024)
44. Surbhi Kumari, Manish Kumar " Molecular Characterization of the ClpC ATPase Chaperone and its Interaction with ClpP isoforms of Pathogenic Leptospira", International Conference on Frontier Areas of Science & Technology-2024 (ICFAST2024), 6 -7 September 2024. Vol., , P.P - , (2024)
45. Prattusha Khan, Manish Kumar "Biochemical characterization of the first enzyme in the rhamnose biosynthetic pathway of pathogenic Leptospira", Research and Industrial Conclave-Integration’24, IIT Guwahati . Vol., , P.P - , (2024)
46. Shibam Dey, Manish Kumar " Investigating the amyloidogenic properties of Hfq , an RNA chaperone of pathogenic Leptospira", Research and Industrial Conclave-Integration’24, IIT Guwahati . Vol., , P.P - , (2024)
47. Prattusha Khan, Manish Kumar " dTTP mediated modulation of LinRfbA activity in Leptospira interrogans during Rhamnose Biosynthesis", Frontiers in Translational Bioengineering For Healthcare ,2025 , Birla Institute of Technology ,Mesra . Vol., , P.P - , (2025)
48. Pratibha Koundal , Manish Kumar " Understanding the functional domains of Trigger Factor (LinTF), a molecular chaperone of Leptospira interrogans", Frontiers in Translational Bioengineering For Healthcare ,2025 , Birla Institute of Technology ,Mesra . Vol., , P.P - , (2025)
Book
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Book Chapter
1. Hussain MS, Kumar M " Stem Cell in Veterinary Science", Springer . Vol., 13:9789811634635, P.P - , (2021)