# Aptamer Name Aptamer Target (General) Aptamer Target (Specific) Length Affinity Buffer GC Content Sequence Reference
161 Trypanosoma cruzi-Thrombospondin Parasite Receptor (T6) Cells Trypanosoma cruzi-Thrombospondin Parasite Receptor 103 400 nM 50 uM RNA containing 20 mM glucose 49.51% 5'-ACCGAGUCCAGAAGCUUGUAGUACUCAAUACUCAAGCAAGCCCAGCCCUACCAACCCCGGAGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC-3' Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.
162 Trypanosoma cruzi-Laminin Parasite Receptor (L28) Cells Trypanosoma cruz-Laminin Parasite Receptor 107 209 nM 50 uM RNA containing 20 mM glucose. 46.73% 5'-ACCGAGUCCAGAAGCUUGUAGUACUUAUGUCCCAUCGAACGCAGUGUAUCUUGCACCGACUCUCUGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC-3' Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.
163 Trypanosoma cruzi-Fibronectin Parasite Receptor (F4) Cells Trypanosoma cruzi-Fibronectin Parasite Receptor 107 124 nM 50 uM RNA containing 20 mM glucose. 53.27% 5'-ACCGAGUCCAGAAGCUUGUAGUACUGACCCUUCCCGACGCACGGACCAGUGAUGCCAACCCACCCGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC-3' Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762.
164 Trypanosoma cruzi-Heparan Parasite Receptor (HS6) Cells Trypanosoma cruzi-Heparan Parasite Receptor 107 40 nM 50 uM RNA containing 20 mM glucose. 52.34% 5'-ACCGAGUCCAGAAGCUUGUAGUACUACCGCAACGUUGGCGUUCGGCGUUGGCCGCGUCAUCGCUAGCCUAGAUGGAGUUGAAUUCUCCCUAUAGUGAGUCGUAUUAC-3' Ulrich et al. "In Vitro Selection of RNA Aptamers That Bind to Cell Adhesion Receptors of Trypanosoma cruzi and Inhibit Cell Invasion." The Journal of Biological Chemistry, 277 (2002): 20756-20762
165 HIV-1 R5 Glycoprotein gp120 (B4) Protein HIV-1 R5 SU Glycoprotein 114 5 nM HBS Buffer (10 mM HEPES (pH 7.4), 150 mM NaCl, 1 mM CaCl2, 1 mM MgCl2, 2.7 mM KCl) 47.37% 5'-AAUUAACCCUCACUAAAGGGAACUGUUGUGAGUCUCAUGUCGAAGAGCGGUUAAGGGAGAUUUAGGCAGCAGCUUGGACAGUGUAUCGGCUGAGUUGAGCGUCUAGUCUUGUCU-3' Khati, M., et al. "Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2'F-RNA Aptamers." Journal of Virology, 77(2003): 12692-12698.
166 PrP Fibrils (SAF-93) Protein PrP Fibrils 116 23.4 nM Binding Buffer (20 mM Hepes (pH 7.2), 100 mM NaCl, 50 mM KCl, 10 mM MgCl2) 49.14% 5'-GGGAGACAAGACUAGACGCUCAACUACGAACUCAUGACACAAGGAUGCAAUCUCAUCCCGCCAGCCCACCGUUUCGACAUGAGACUCACAACAGUUCCCUUUAGUGAGGGUUAAUU-3' Rhie, A., et al. "Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion." Journal of Biological Chemistry, 278 (2003): 39697-705.
167 HIV-1 R5 SU Glycoprotein gp120 (B40) Protein HIV-1 R5 gp120 117 21 nM cHBS buffer: 10 mM HEPES, pH 7.4, 150 mM NaCl, 1 mM CaCl 2, 1 mM MgCl2, 2.7 mM KCl 48.72% 5'-GGGAGACAAGACUAGACGCUCAAUGUGGGCCACGCCCGAUUUUACGCUUUUACCCGCACGCGAUUGGUUUGUUUUCGACAUGAGACUCACAACAGUUCCCUUUAGUGAGGGUUAAUU-3' A. K. Dey et. al. Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1. RNA 11:873-884
168 Osteopontin (2-O-Me OPN-R3) Protein Human Osteopontin 40 18 nM Binding Buffer: PBS (137 nM NaCl, 27 nM KCl, 100 nM Na2HPO4, 2 nM K2HPO4, pH 7.4) 45.00% 5'-CGGCCACAGAAUGAAAAACCUCAUCGAUGUUGCAUAGUUG-3' Z Mi et al. RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Molecular Therapy 17(2009): 153-161
169 2'-O-Methyl modified RNA aptamer Protein p53 75 N/A nM 0.15 mM Hepes [pH 7.4], 0.3 mM KCl, 6 uM dithiothreitol [DTT], 6 uM MgCl2, 1.1 uM ethylenediaminetetraacetic acid [EDTA], 6% glycerol, and 3 uM phenylmethanesulfonyl fluoride [PMSF] 48.00% 5'-GGGCGAAUUCGGGUUGGAUAGUAGGCGCAUAUGGCAUCUUCGUGGUUGUGUAUUGCCCUUUAGUGAGGGUUAAUU-3' Shwetha, N. et al. "Aptamerƒ??nanoparticle-based chemiluminescence for p53 protein." Analytical Biochemistry 2013, 441: 73-79.
170 Acetylcholine Receptor Antibody (mAB198) Protein Acetylcholine Receptor Antibody (mAB198) 48 60 nM Binding Buffer (30mM Tris-HCl (pH 7.5), 150 mM NaCl, 10mM MgCl2, 2mM dithiothreitol, 1% BSA) 68.75% 5'-UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA-3' Lee, Seong-Wook and Sullenger, Bruce. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15 (1997): 41-45.