# Aptamer Name Aptamer Target (General) Aptamer Target (Specific) Length Affinity Buffer GC Content Sequence Reference
181 Gonadotropin-releasing hormone 1 (60-mer S42) Peptide Gonadoliberin/Gonadotropin-releasing hormone 1 (GnRH) 60 45 nM Selection Buffer: 10 mM HEPES (pH 7.5), 137 mM NaCl, 2.7 mM KCl, 2 mM CaCl22, 1 mM MgCl2, 0.005% Triton X-100 80.00% 5'-GCGGCGGAGGGTGGGCTGGGGCTGGGCCGGGGGGCGTGCGTAAGCACGTAGCCTCGCCGC-3' Leva, S., et al. "GnRH Binding RNA and DNA Spiegelmers: A Novel Approach toward GnRH Antagonism." Chemistry and Biology, 9 (2002): 351-359.
182 Anti-VEGF165 Unnatural Base DNA Aptamer Protein VEGF165 56 0.9 pM 1× PBS (1 mM KH2PO4, 3 mM Na2HPO4 and 155 mM NaCl, pH 7.4, Gibco) 5'-GCGGTAAACTGCGTCCGAAGGGGCTGCAGTGACCCGAATGGGTCCGCCGCGAAGCG-3' Kimoto M., Nakamura M., Hirao I. July 7 2016. Post-ExSELEX stabilization of an unnatural-base DNA aptamer targeting VEGF165 toward pharmaceutical applications. Nucleic Acids Research 44(15): 7487-7494.
183 SL1025 Protein Interleukin 6 (IL-6), cytokine 22 0.2 nM PBS with 1%BSA, 0.05% Tween 20, 5 mM MgCl2 68.18%
184 Human Immunoglobulin G (IgG) Protein hlgG-Fc 23 90.9 nM Binding Buffer (145mM NaCl, 5.4 mM KCl, 0.8mM MgCl, 1.8 mM CaCl, and 20 mM Tris-HCl (pH 7.6)) 60.87% 5'-GGAGGUGCUCCGAAAGGAACUCC-3' Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
185 Vascular Permeability Factor/Vascular Endothelial Growth Factor (NX-213) Protein Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) 32 140 pM Selection Buffer (PBS: 10.1 mM Na2HPO4, 1.8 mM KH2PO4, 137 mM NaCl and 2.7 mM KCl (pH 7.4)) with 0.01 % human serum albumin 50.00% 5'-TTTTACCCUGAUGGUAGACGCCGGGGUGTTTT-3' Green L, Jellinek D, Janjic N, et al. (1995) "Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor." Chem Biol. 2:683-695.
186 Human Matrix Metalloprotease 9 (hMMP-9) Protein Human matrix metalloprotease 9 (hMMP-9) 36 20 nM SP buffer: 50 mM Tris HCl, pH 7.4, 50 mM NaCl, 100 mM KCl, 5 mM CaCl2, 1 mM Magnesium Acetate. 72.22% 5'-UGCCCUGCCCUCACCCGUUAGCCUGAGCGCCCCGCA-3' S Gomes et al. A 99mTc-MAG3-aptamer for imaging human tumours associated with high level of matrix metalloproteinase-9. Bioconjugate Chem. (2012). Accepted for print. DOI: 10.1021/bc300146c.
187 Membrane-Bound IgM (TD05.17) Protein Membrane-bound IgM (mIgM )/ B-cell receptor (BCR )/ Leukemia / Lymphoma 37 43 nM Binding Buffer: RPMI 1640, 4.5 g/L glucose, 5 mM MgCl2 in vivo (20 mM MgCl2 in vitro), 100 mg/L tRNA and 100 mg/L BSA. 56.76% 5'-AGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCT-3' R Mallikaratchy et al. "A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemia." Nucleic Acids Res. 39(2011): 2458-2469.
188 Carcinoembryonic Antigen Aptamer (YJ-1) Protein Carcinoembryonic Antigen (CEA) 49 0.77 nM 30 mM Tris-HCL, 150 mM NaCK, 1.5 mM MgCl2, 2 mM dithiothreitol, 1% bovine serum albumin, pH 7.5 42.86% 5'-GCGGAAGCGUGCUGGGCUAGAAUAAUAAUAAGAAAACCAGUACUUUCGU-3' YJ Lee et al. An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology 143(2012): 155-165.
189 Chagas Apt-79 Protein T. cruzi Excreted Secreted Antigens (TESA) 72 PBS, mouse plasma 40.28%
190 Angiogenic endothelial cells  Tissue Aminopeptidase N 3 N/A nM Wash buffer in cellular association assays: PBS.  NH2-NGR-COOCOOH Pastorino et al. "Vascular Damage and Anti-angiogenic Effects of Tumor Vessel-Targeted Liposomal Chemotherapy." Cancer Research, 63(2003): 7400-7409