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# | Aptamer Name | Aptamer Target (General) | Aptamer Target (Specific) | Length | Affinity | Buffer | GC Content | Sequence | Reference |
---|---|---|---|---|---|---|---|---|---|
201 | RGD motifs in Fibronectin and Vitronectin | Protein | RGD motifs in Fibronectin and Vitronectin | 8 | N/A nM | TBS Wash Buffer | NH2-CWDDGWLC-COOCOOH | Pasqualini et al. "A Peptide Isolated from Phage Display Libraries Is a Structural and Functional Mimic of an RGD-binding Site on Integrins." The Journal of Cell Biology, 130(1995): 1189-1196. | |
202 | Human Breast Cancer Xenografts (RGD-4C) | Tissue | Human Breast Cancer Xenografts | 9 | N/A nM | In vivo mice. | NH2-CDCRGDCFC-COOCOOH | Arap et al. "Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model." Science, 279(1998): 377-380. | |
203 | Brain Vasculature | Tissue | Brain Vasculature | 9 | N/A nM | In vivo mice. | NH2-CLSSRLDAC-COOCOOH | Pasqualini and Ruoslahti. "Organ targeting in vivo using phage display peptide libraries." Letters to Nature, 380(1996):364-366. | |
204 | VCAM-1 | Tissue | VCAM-1 | 9 | N/A nM | Washed with PBS containing 0.1% Tween-20. | NH2-CVHSPNKKC-COOCOOH | Kelly et al. "Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle." Journal of the American Heart Association, 96(2005): 327-33. | |
205 | Mouse Retina | Tissue | Mouse Retina | 9 | N/A nM | In vivo in mice. | NH2-CSCFRDVCC-COOCOOH | D Rajotte et al. " Molecular Heterogeneity of the Vascular Endothelium Revealed by In Vivo Phage Display." Journal of Clinical Investigations, 102(1998): 430-437. | |
206 | Mouse Pancreas Vasculature | Tissue | Mouse Pancreas Vasculature | 9 | N/A nM | In vivo in mice. | NH2-SWCEPGWCR-COOCOOH | D Rajotte et al. " Molecular Heterogeneity of the Vascular Endothelium Revealed by In Vivo Phage Display." Journal of Clinical Investigations, 102(1998): 430-437. | |
207 | Mouse White Fat | Tissue | 9 | N/A nM | N/A | NH2-CKGGRAKDC-COOCOOH | Kolonin et al. "Teratogenicity induced by targeting a placental immunoglobulin transporter." PNAS, 99(2002): 13055-13060. | ||
208 | Interleukin 11 receptor (IL-11Ra) Human Prostate | Tissue | Interleukin 11 receptor (IL-11Ra) | 9 | N/A nM | In vivo in a patient. | NH2-CGRRAGGSC-COOCOOH | Arap et al. "Steps toward mapping the human vasculature by phage display." Nature Medicine, 8(2002): 121-127. | |
209 | Islets of Langerhans | Tissue | Islets of Langerhans | 9 | N/A nM | In vivo in mice with body temperature maintained at 37 °C. | NH2-CVSNPRWKC-COOCOOH | Yao et al. "Targeting Pancreatic Islets with Phage Display Assisted by Laser Pressure Catapult Microdissection." American Journal of Pathology, 166(2005): 625-636. | |
210 | Human Gastric Adenocarcinoma | Tissue | Human Gastric Adenocarcinoma | 9 | N/A nM | In vivo in human tumor xenograft mice. | NH2-CGNSNPKSC-COOCOOH | Zhi et al. "Characterization of a Specific Phage-Displayed Peptide Binding to Vasculature of Human Gastric Cancer." Cancer Biology & Therapy, 3(2004): 1232-1235. |