# Aptamer Name Aptamer Target (General) Aptamer Target (Specific) Length Affinity Buffer GC Content Sequence Reference
431 Aspartame Protein Aspartame 99 5 mM Selection Buffer (150 mM NaCl, 10 mM MgCl2, 1 mM EDTA, 10 mM Sodium Phosphate, 90 mM HEPES (pH 7.1)) Assay Buffer (180mM HEPES (pH 7.0±8.0), 300 mM NaCl, 20 or 50 mM MgCl2, 2 mM EDTA, 20 mM Na phosphate), r.t. 51.52% 5' GGAUGUCCAGUCGCUUGCAAUGCCCUUUUAGACCCUGAUGAGCGGUGCUAGUUAGUUGCAGUUUCGGUUGUUACGCGAAACGGUGAAAGCCGUAGGUCU 3' Ferguson et al. "A novel strategy for selection of allosteric ribozymes yields RiboReporter TM sensors for caffeine and aspartame." Nucleic Acids Research, 32(2004): 1756-1766.
432 RNA Tobramycin Molecular Beacon (BA 14-2) Small Organic Tobramycin 104 16 µM Binding buffer: 50 mM Tris (pH 7.4), 500 mM NaCl 48.08% 5' GGAAUGGAUCCACAUCUACGAAGGCUUUGAAGGUGAGACCGUGCAAAUGAGGAUGGUGUGGAUGAUUAGGGUUGUCGGUUUUCACUGCAGACUUGACGAAGCUU 3' Morse, Daniel. "Direct selection of RNA beacon aptamers." Biochemical and Biophysical Research Communications, 359 (2007): 94ƒ??101.
433 L-tryptophan(Trp 70-727) Protein L-tryptophan 104 15 nM  Selection buffer: 50 mM HEPES (pH 7.0), 250 mM NaCl, 5 mM MgCl2, 5 mM CaCl2, 5 mM glycine 59.62% 5' GGGAUCCUAAGCUCUAUCGGCUGGACGACGGGGACGCCACUGGACUAGGUAAGCCAGGACCGUACGUCGGGAGCCGUCAGAAUAAAAGCGGCCUAGCGAUCGAU 3' Majerfeld and Yarus. "A diminutive and specific RNA binding site for L-tryptophan." Nucleic Acids Research, 33(2005): 5482-5493.
434 C-Reactive Protein (CRP1-1) Protein C-Reactive Protein (CRP) 104 2.25 nM Binding Buffer: 20 mM Tris-HCl (pH 7.5), 140 mM NaCl, 2 mM CaCl2and 1 mM MgCl2.  53.85% 5' GGGCGAAUUCGGGACUUCGAUCCGUAGUACCCACCAGGCAUACACCAGCACGCGGAGCCAAGGAAAAAUAGUAAACUAGCACUCAGUGCUCGUAUGCGGAAGCU 3' N Orito, Y Kikuchi, et al. High-affinity RNA aptamers to C-reactive protein (CRP): newly developed pre-elution methods for aptamer selection. J. Phys. Conf. Ser. 352(2012): 012042. doi:10.1088/1742-6596/352/1/012042.
435 ATP C32 Small Organic ATP 104 27 µM (50 mM Tris–HCl, pH 7.5, 150 mM NaCl, 5 mM MgCl2) + 1 mg/ml tRNA and 0.1 mg/ml BSA 49.04% Weill L., Louis D., and Sargueil B., 2004.Selection and Evolution of NTP-Specific Aptamers. Nucleic Acids Research, 2004 Vol. 32 No. 17, 5045-5058
436 Interleukin-6 receptor (AIR-3) Protein Soluable interleukin-6 receptor (sIL-6R) 106 19.7 nM Selection Buffer (used for Filter Retention Assay): 137 mM NaCl, 2.7 mM KCl, 6.5 mM Na2HPO4, and 3 mM MgCl2 at PH 7.5. 45.28% 5' GGAAGAAAGAGGUCUGAGACAUUCUCUUAUAGGGGAGGCUGUGGUGAGGGAAUAUUAAGAGAAUUAACGGUCUAGUUCACCUCGACUUCUGGAGUUGACGUUGCUU 3' Meyer C, U Hahn, et al. (2012) Interleukin-6 Receptor specific RNA aptamers for cargo delivery into target cells. RNA Biol
437 ATP C27 Small Organic ATP 106 21 µM (50 mM Tris–HCl, pH 7.5, 150 mM NaCl, 5 mM MgCl2) + 1 mg/ml tRNA and 0.1 mg/ml BSA 51.89% Weill L., Louis D., and Sargueil B., 2004.Selection and Evolution of NTP-Specific Aptamers. Nucleic Acids Research, 2004 Vol. 32 No. 17, 5045-5058
438 Amyloid Peptide BetaA4(1– 40) (B55) Peptide Amyloid Peptide BetaA4(1– 40) 107 29 nM Binding Buffer (10 mM Tris–HCl (pH 7.5), 150 mM NaCl, 5 mM MgCl2, 1 mM EDTA). Incubated at room temperature. 54.21% 5' GGGAAUUCGAGCUCGGUACCUUUACCGUAAGGCCUGUCUUCGUUUGACAGCGGCUUGUUGACCCUCACACUUUGUACCUGCUGCCAACUGCAGGCAUGCAAGCUUGG 3' Ylera, Francisco, et al. "Selection of RNA Aptamers to the Alzheimer's Disease Amyloid Peptide." Biochemical and Biophysical Research Communities, 290 (2002): 1583-1588.
439 SARS Coronavirus NTPase/Helicase (ES15-1) Protein SARS Coronavirus NTPase/Helicase 107 1.2 nM Binding Buffer (30 mM Tris–HCl (pH 7.5), 150 mM NaCl, 1.5 mM MgCl2 , 2 mM dithiothreitol (DTT) and 1% (w/v) BSA) Termination Buffer (0.2 M EDTA, 0.2 M NaCl, and 20 mM HEPES (pH 7.4)) Buffer A (25 mM Tris–HCl (pH 7.5), and 0.3 mM NaCl) 46.73% 5' GAUAAUACGACUCACUAUAGGGUUCACUGCAGACUUGACGAAGCUUGCAGAAAAGGGGGAAGAAGAGGGUGAUUCAGGCGAGAGAAUGGAUCCACAUCUACGAAUUC 3' Jang, K., et al. "Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase." Biochemical and Biophysical Research Communications, 366(2008): 738-744.
440 Tobramycin (J6) Small Organic Tobramycin 109 2 nM Selection Buffer: 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1mM MgCl2, and 20 mM Tris Acetate (pH 7.4) 51.38% 5' GGGAGAAUUCCGACCAGAAGCUUAGUAUAGCGAGGUUUAGCUACACUCGUGCUGAUCGUUUGGUACGGGACCUGCGUGUAGCCCAUAUGUGCGUCUACAUGGAUCCUCA 3' Wang, Yong, et al. "Specific binding of aminoglycoside antibiotics to RNA." Chemistry & Biology 2 (1995): 281-290