# Aptamer Name Aptamer Target (General) Aptamer Target (Specific) Length Affinity Buffer GC Content Sequence Reference
171 Anti-acetylcholine Autoantibodies (SE RNA) Protein Anti-acetylcholine Autoantibodies 48 60 nM Binding Buffer (30 mM Tris-HCl (pH 7.5), 150 mM NaCl, 10 mM MgCl2, 2 mM DTT, 1% BSA) 68.75% 5'-UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA-3' Lee and Sullenger. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15(1997):
172 Moenomycin A (C2) Small Organic Moenomycin A 51 350 nM Binding buffer: 20mM HEPES (pH 7.4), 150mM NaCl, and 5mM MgCl2 70.59% 5'-GGAGGUCGACCUCGCGCGAGGAGGGUGGAGGGUCGUAGAGCGCGUAGGAGG-3’ Heike, S., et al. "Aptamers that bind to the antibiotic moenomycin A." Bioorganic & Medicinal Chemistry, 9 (2001): 2557-2563.
173 Human Nonpancreatic Secretory Phospholipase A2 (Aptamer 15) Small Organic Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2) 51 1.7 nM Tris-buffered saline (25 mM Tris, pH 7.4, 150 mM NaCl) Tris potassium calcium buffer (25 mM Tris, 2.5 mM CaCl2, 100 mM KCl) 62.75% 5'-GGGAAAAGAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGCCGAGAA-3' Bridonneau, P., et al. "High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)." Journal of Medicinal Chemistry, 41(1998): 778-786.
174 Interferon-? (2'NH2-17) Protein Interferon-y/IFN-y/IFNG 69 1.7 nM  Binding Mixture: PBS (138 mM NaC1, 2.7 mM KCl, 8.1 mM Na2HPO4, and 1.1 mM KH2PO4, pH 7.4) containing 1 mM Mg2+ ions and 0.01% human serum albumin. 63.77% 5'-GGGAGGACGAUGCGGUGGUAGCGCGAUAUAGCGCUGGUAGGGUUGCCGGUGAUCAGACGACUCGCCCGA-3' Kubik, Mark F., et al. "Isolation and Characterization of 2ƒ??-Fluoro-, 2ƒ??-Amino-, and 2ƒ??-Fluoro-/Amino-Modified RNA Ligands to Human IFN-7 That Inhibit Receptor Binding." Journal of Immunology, 159 (1997): 259-267
175 Interferon-? (2'NH2-30)  Protein Interferon-y/IFN-y/IFNG 70 2.7 nM Binding Mixture: PBS (138 mM NaC1, 2.7 mM KCl, 8.1 mM Na2HPO4, and 1.1 mM KH2PO4, pH 7.4) containing 1 mM Mg2+ ions and 0.01% human serum albumin. 55.71% 5'-GGGAGGACGAUGCGGCAGGUAAUUACAUGAAGGUGGGUUAGGUACUUUCAGGGUCAGACGACUCGCCCGA-3' Kubik, Mark F., et al. "Isolation and Characterization of 2ƒ??-Fluoro-, 2ƒ??-Amino-, and 2ƒ??-Fluoro-/Amino-Modified RNA Ligands to Human IFN-7 That Inhibit Receptor Binding." Journal of Immunology, 159 (1997): 259-267.
176 Insulin Receptor Antibody (MA20) Antibody Insulin Receptor Antibody (MA20) 86 30 nM Binding buffer: 30 mM Tris-HCl (pH 7.5), 150 mM NaC1, 10 mM MgC12, 2 mM dithiothreitol, and 1.0% BSA 58.14% 5'-GGGAGAGCGGAAGCGUGCUGGGCCUGGUUGCUGUAAAAAUAGACACGAAUCUGCCGACCAUAACCCAGAGGUCGAUGGAUCCCCCC-3' Lee, Seong-Wook and Sullenger, Bruce A. "Isolation of a Nuclease-resistant Decoy RNA That Selectively Blocks Autoantibody Binding to Insulin Receptors on Human Lymphocytes." Journal of Experimental Medicine, 184 (1996): 315-324.
177 Prion Protein Protein Prion Protein 86 100 nM Binding Buffer (8um urea, 20 mm sodium phosphate, 500 mm sodium chloride (pH 7.8)) Selection Buffer (155 mM NaCl, 1.1 mM KH2PO4, 3.0 mM Na2HPO4, 1.0 mM MgCl2 (pH 7.4)) 56.98% 5'-GGGAGAAAGGGAAGCUUGAGGUGCUAUGGAGUGGAGGAGUUGAAGGUGUCGGGGUUGGCAGAAGAAGGCGAGCGUACGGAUCCAUC-3' Proske et al. "Prion-Protein-Specific Aptamer Reduces PrPSc Formation." Chem-Biochem, 3(2002): 717-725.
178 Neuropeptide Y (DP3)  Peptide Neuropeptide Y (NPY) 90 370 nM Binding Buffer: 0.9 mM KH2P4, Na2HPO4, 70 mM NaCL, 1.3 mM KCl, 1% heparin, 0.4 g/l of streptavidin, pH 7.6. 57.78% 5'-GGGAGAAAGGGAAGCUUGAGCAGCAGGAGGGCCGGCGUUAGGGUUAGCGAGCCGAUUGAAAGAAGAAGGAACGAGCGUACGGAUCCGAUC-3' D. Proske et al. A Y2 receptor mimetic aptamer directed against neuropeptide Y. J. Biol. Chem. 277(2002):11416-11422.
179 Gonadotropin-releasing hormone 1 (A10) Peptide Gonadoliberin/Gonadotropin-releasing hormone 1 (GnRH) 50 190 nM Selection Buffer: 10 mM HEPES (pH 7.5), 137 mM NaCl, 2.7 mM KCl, 2 mM CaCl22, 1 mM MgCl2, 0.005% Triton X-100 52.00% 5'-CGGCCGAUAGAAAGACUACUUGAGCCCUUAAAUGAGGUUAUGUGCGGCCG-3’ Leva, S., et al. "GnRH Binding RNA and DNA Spiegelmers: A Novel Approach toward GnRH Antagonism." Chemistry and Biology, 9 (2002): 351-359.
180 L-vasopressin Peptide L-vasopressin/arginine vasopressin/AVP/ADH 55 1.2 µM Buffer B: 20 mM sodium 2-[bis(2-hydroxyethyl)amino]ethane sulfonate, pH 7.3, with 140 mM NaCl, 5 mM KCl, 1.5 mM MgCl2, 1 mM CaCl2, and 0.02% Triton X-100. 58.18% 5'-TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA-3' K. P. Williams, D. P. Bartel, et al. Bioactive and nuclease-resistant l-DNA ligand of vasopressin. Proc. Natl. Acad. Sci., USA. 94(1997): 11285-11290.